[HTML][HTML] The RHO family GTPases: mechanisms of regulation and signaling
N Mosaddeghzadeh, MR Ahmadian - Cells, 2021 - mdpi.com
Much progress has been made toward deciphering RHO GTPase functions, and many
studies have convincingly demonstrated that altered signal transduction through RHO …
studies have convincingly demonstrated that altered signal transduction through RHO …
The guanine nucleotide-binding switch in three dimensions
IR Vetter, A Wittinghofer - Science, 2001 - science.org
Guanine nucleotide–binding proteins regulate a variety of processes, including sensual
perception, protein synthesis, various transport processes, and cell growth and …
perception, protein synthesis, various transport processes, and cell growth and …
Biology of the p21-activated kinases
GM Bokoch - Annual review of biochemistry, 2003 - annualreviews.org
▪ Abstract The p21-activated kinases (PAKs) 1–3 are serine/threonine protein kinases whose
activity is stimulated by the binding of active Rac and Cdc42 GTPases. Our understanding of …
activity is stimulated by the binding of active Rac and Cdc42 GTPases. Our understanding of …
Rho family proteins: coordinating cell responses
AJ Ridley - Trends in cell biology, 2001 - cell.com
Rho GTPases hit the headlines several times in 1990–1992: the proteins regulating their
GTP–GDP cycle were identified and they were found to be key signal transducers, mediating …
GTP–GDP cycle were identified and they were found to be key signal transducers, mediating …
p21-activated kinases in cancer
R Kumar, AE Gururaj, CJ Barnes - Nature Reviews Cancer, 2006 - nature.com
The pivotal role of kinases in signal transduction and cellular regulation has lent them
considerable appeal as pharmacological targets across a broad spectrum of cancers. p21 …
considerable appeal as pharmacological targets across a broad spectrum of cancers. p21 …
[HTML][HTML] Functional dysregulation of CDC42 causes diverse developmental phenotypes
S Martinelli, OHF Krumbach, F Pantaleoni… - The American Journal of …, 2018 - cell.com
Exome sequencing has markedly enhanced the discovery of genes implicated in Mendelian
disorders, particularly for individuals in whom a known clinical entity could not be assigned …
disorders, particularly for individuals in whom a known clinical entity could not be assigned …
[HTML][HTML] Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
M Lei, W Lu, W Meng, MC Parrini, MJ Eck, BJ Mayer… - Cell, 2000 - cell.com
The p21-activated kinases (PAKs), stimulated by binding with GTP-liganded forms of Cdc42
or Rac, modulate cytoskeletal actin assembly and activate MAP-kinase pathways. The 2.3 Å …
or Rac, modulate cytoskeletal actin assembly and activate MAP-kinase pathways. The 2.3 Å …
Calmodulin interacts with MLO protein to regulate defence against mildew in barley
MC Kim, R Panstruga, C Elliott, J Müller, A Devoto… - Nature, 2002 - nature.com
In plants, defence against specific isolates of a pathogen can be triggered by the presence
of a corresponding race-specific resistance gene, whereas resistance of a more broad …
of a corresponding race-specific resistance gene, whereas resistance of a more broad …
A tale of two Paks
LE Arias‐Romero, J Chernoff - Biology of the Cell, 2008 - Wiley Online Library
Paks (p21‐activated kinases) are effectors for the small GTPases Cdc42 (cell division cycle
42) and Rac that play fundamental roles in a wide range of cellular processes, including cell …
42) and Rac that play fundamental roles in a wide range of cellular processes, including cell …
Regulation of G protein–initiated signal transduction in yeast: paradigms and principles
HG Dohlman, J Thorner - Annual review of biochemistry, 2001 - annualreviews.org
▪ Abstract All cells have the capacity to evoke appropriate and measured responses to signal
molecules (such as peptide hormones), environmental changes, and other external stimuli …
molecules (such as peptide hormones), environmental changes, and other external stimuli …