Much progress has been made toward deciphering RHO GTPase functions, and many
studies have convincingly demonstrated that altered signal transduction through RHO …

Guanine nucleotide–binding proteins regulate a variety of processes, including sensual
perception, protein synthesis, various transport processes, and cell growth and …

▪ Abstract The p21-activated kinases (PAKs) 1–3 are serine/threonine protein kinases whose
activity is stimulated by the binding of active Rac and Cdc42 GTPases. Our understanding of …

Rho GTPases hit the headlines several times in 1990–1992: the proteins regulating their
GTP–GDP cycle were identified and they were found to be key signal transducers, mediating …

The pivotal role of kinases in signal transduction and cellular regulation has lent them
considerable appeal as pharmacological targets across a broad spectrum of cancers. p21 …

Exome sequencing has markedly enhanced the discovery of genes implicated in Mendelian
disorders, particularly for individuals in whom a known clinical entity could not be assigned …

The p21-activated kinases (PAKs), stimulated by binding with GTP-liganded forms of Cdc42
or Rac, modulate cytoskeletal actin assembly and activate MAP-kinase pathways. The 2.3 Å …

In plants, defence against specific isolates of a pathogen can be triggered by the presence
of a corresponding race-specific resistance gene, whereas resistance of a more broad …

Paks (p21‐activated kinases) are effectors for the small GTPases Cdc42 (cell division cycle
42) and Rac that play fundamental roles in a wide range of cellular processes, including cell …

▪ Abstract All cells have the capacity to evoke appropriate and measured responses to signal
molecules (such as peptide hormones), environmental changes, and other external stimuli …