The intrinsic or acquired resistance to anticancer drugs remains one of the most significant
factors impeding the progress of cancer chemotherapy. This phenomenon often involves …

Metastatic disease is the most common mechanism of death in patients with advanced
bladder cancer. As for most solid tumors, chemotherapy remains the only realistic option for …

Prediction of P-glycoprotein substrate specificity (S PGP) can be viewed as a constituent part
of a compound's “pharmaceutical profiling” in drug design. This task is difficult to achieve …

Anti-angiogenic therapy, which suppresses tumor growth by disrupting oxygen and nutrient
supply from blood to the tumor, is now widely accepted as a treatment for cancer. To …

One of the major challenges in the development of targeted nanoparticles (NPs) for cancer
therapy is to discover targeting ligands that allow for differential binding and uptake by the …

P-glycoprotein (P-gp) actively transports a wide variety of chemically diverse compounds out
of cells. It is highly associated with the ADMET properties of drugs and drug candidates and …

We undertook a systematic review of the pre-clinical and clinical literature for studies
investigating the relationship between platinum and taxane resistance. Medline was …

Three new mixed-ligand oxidovanadium (IV) complexes [VIVOL1–2 (LN–N)](1–3) have
been synthesized using two tridentate bi-negative–ONS chelating dithiocarbazate ligands …

Recent studies found that short-chain fatty acids (SCFAs), which are produced through
bacterial fermentation in the gastrointestinal tract, have oncoprotective effects against …

Purpose While the benefits of ascorbic acid (vitamin C, ascorbate) as an essential nutrient
are well established, its effects on tumor cells and in tumor treatment are controversial. In …