[HTML][HTML] An overview on androgen-mediated actions in skeletal muscle and adipose tissue

J Rizk, R Sahu, D Duteil - Steroids, 2023 - Elsevier
Androgens are a class of steroid hormones primarily associated with male sexual
development and physiology, but exert pleiotropic effects in either sex. They have a crucial …

[HTML][HTML] Advances in mitochondria-centered mechanism behind the roles of androgens and androgen receptor in the regulation of glucose and lipid metabolism

L Yin, S Qi, Z Zhu - Frontiers in Endocrinology, 2023 - frontiersin.org
An increasing number of studies have reported that androgens and androgen receptors
(AR) play important roles in the regulation of glucose and lipid metabolism. Impaired …

[HTML][HTML] Filamin A cooperates with the androgen receptor in preventing skeletal muscle senescence

M Di Donato, A Moretti, C Sorrentino, G Toro… - Cell Death …, 2023 - nature.com
Aging induces a slow and progressive decrease in muscle mass and function, causing
sarcopenia. Androgens control muscle trophism and exert important anabolic functions …

[HTML][HTML] LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice

Q Cai, R Sahu, V Ueberschlag-Pitiot… - Nature …, 2024 - nature.com
Synthetic glucocorticoids (GC), such as dexamethasone, are extensively used to treat
chronic inflammation and autoimmune disorders. However, long-term treatments are limited …

Differences in branched-chain amino acid to tyrosine ratio (BTR) among etiologies of chronic liver disease progression compared to healthy adults.

M Mino, A Sano, E Kakazu, H Matsubara… - Journal of …, 2024 - Springer
Background The branched-chain amino acids (BCAAs) to tyrosine (Tyr) ratio (BTR) test is
used to evaluate the progression of chronic liver disease (CLD). However, the differences …

[HTML][HTML] Type I fiber decrease and ectopic fat accumulation in skeletal muscle from women with PCOS

E Stener-Victorin, G Eriksson, MM Shrestha, VR Paris… - eLife, 2023 - elifesciences.org
Polycystic ovary syndrome's (PCOS) main feature is hyperandrogenism, which is linked to a
higher risk of metabolic disorders in women. Gene expression analyses in adipose tissue …

Growth increase and gonadal dysfunction of the lined seahorse triggered by zinc exposure

X Han, C Li, G Qin, X Wang, B Zhang, Q Lin - Aquatic Toxicology, 2024 - Elsevier
Seahorses are characterized by unique characteristics such as a male pregnancy
reproductive strategy and grasping preferences, which make these species vulnerable to …

Lifespan effects of muscle-specific androgen receptor overexpression on body composition of male and female rats

ST Barsky, DA Monks - Endocrinology, 2024 - academic.oup.com
Androgenic actions of gonadal testosterone are thought to be a major mechanism promoting
sex differences in body composition across the lifespan. However, this inference is based on …

[HTML][HTML] Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with PCOS

E Stener-Victorin, G Eriksson, MM Shrestha, VR Paris… - Elife, 2024 - elifesciences.org
Background: Polycystic ovary syndrome's (PCOS) main feature is hyperandrogenism, which
is linked to a higher risk of metabolic disorders. Gene expression analyses in adipose tissue …

The roles of sex hormones in the pathophysiology of age‐related sarcopenia and frailty

T Hosoi, M Yakabe, S Hashimoto… - Reproductive …, 2024 - Wiley Online Library
Background Sarcopenia is an age‐related condition characterized by a progressive and
systemic decline in skeletal muscle mass, quality, and strength. The incidence of sarcopenia …