Oxidative stress and natural antioxidants in osteoporosis: Novel preventive and therapeutic approaches

G Marcucci, V Domazetovic, C Nediani, J Ruzzolini… - Antioxidants, 2023 - mdpi.com
This review reports in detail the cellular and molecular mechanisms which regulate the bone
remodeling process in relation to oxidative stress (OS), inflammatory factors, and estrogen …

Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response

V Kostenko, O Akimov, O Gutnik, H Kostenko… - Heliyon, 2023 - cell.com
One of the adverse outcomes of acute inflammatory response is progressing to the chronic
stage or transforming into an aggressive process, which can develop rapidly and result in …

Ferroptosis-a new target of osteoporosis

Z Gao, Z Chen, Z Xiong, X Liu - Experimental gerontology, 2022 - Elsevier
Osteoporosis is a bone metabolic disease characterized by reduced bone mass and
deterioration of bone tissue microarchitecture, leading to enhanced skeletal fragility and …

ROS-activatable biomimetic interface mediates in-situ bioenergetic remodeling of osteogenic cells for osteoporotic bone repair

M Chen, M Li, Y Wei, C Xue, M Chen, Y Fei, L Tan… - Biomaterials, 2022 - Elsevier
Bioenergy (ATP) is essentially required for supporting the osteogenic differentiation of bone
marrow mesenchymal stem cells (MSCs). However, factors such as high ROS levels and …

Prussian blue nanozyme normalizes microenvironment to delay osteoporosis

C Ye, W Zhang, Y Zhao, K Zhang… - Advanced …, 2022 - Wiley Online Library
Osteoporosis (OP) is the most common orthopedic disease in the elderly and the main
cause of age‐related mortality and disability. However, no satisfactory intervention is …

The “three in one” bone repair strategy for osteoporotic fractures

X Chen, Y Hu, Z Geng, J Su - Frontiers in endocrinology, 2022 - frontiersin.org
In aging society, osteoporotic fractures have become one major social problem threatening
the health of the elderly population in China. Compared with conventional fractures, low …

[HTML][HTML] The RANK/RANKL/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies

Y Zhang, J Liang, P Liu, Q Wang, L Liu… - Frontiers in …, 2022 - frontiersin.org
With the markedly increased diagnosis and incidence of cancer in the population, tumor
bone metastasis has become a frequent event in tumor patients. Healthy bone integrity is …

A Glutathione Peroxidase‐Mimicking Nanozyme Precisely Alleviates Reactive Oxygen Species and Promotes Periodontal Bone Regeneration

B Zhu, J Wu, T Li, S Liu, J Guo, Y Yu… - Advanced …, 2024 - Wiley Online Library
The use of oxidoreductase nanozymes to regulate reactive oxygen species (ROS) has
gradually emerged in periodontology treatments. However, current nanozymes for treating …

Research progress of ferroptosis regulatory network and bone remodeling in osteoporosis

C Yan, J Zhang, F An, J Wang, Y Shi, L Yuan… - Frontiers in Public …, 2022 - frontiersin.org
Ferroptosis was induced the programmed cell death with iron overload Fenton reaction.
Currently, ferroptosis has not been studied thoroughly. Existing studies have confirmed that …

Citropten Ameliorates Osteoclastogenesis Related to MAPK and PLCγ/Ca2+ Signaling Pathways through the Regulation of Amyloid Beta

NM Trang, EN Kim, TH Pham… - Journal of Agricultural and …, 2023 - ACS Publications
Osteoporosis and Alzheimer's disease are typical types of dementia in seniors, which share
common risk factors. Previous studies have shown that citizens with osteoporosis are more …