The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Ovarian clear cell (OCCC) and endometrioid (EnOC) carcinomas are often subsumed under
the umbrella term “endometriosis-associated ovarian cancer”(EAOC), since they frequently …

Simple Summary Inflammation is like the proverbial double-edged sword. Controlled short-
term inflammation could be a protective response while uncontrolled inflammation sustains …

Quinolizidine alkaloids, as essential active ingredients extracted from Sophora
alopecuroides Linn, have been well concerned in the past several decades owing to the …

Breast cancer is the most prevalent type of cancer among women. Several types of drugs,
targeting the specific proteins expressed on the breast cancer cell surface (such as receptor …

Background In breast cancer, complex interactions between tumor cells and cells within the
surrounding stroma, such as macrophages, are critical for tumor growth, progression, and …

Adhesion of acute lymphoblastic leukemia (ALL) cells to bone marrow stroma cells triggers
intracellular signals regulating cell-adhesion-mediated drug resistance (CAM-DR). Stromal …

A large number of nutrients and bioactive ingredients found in milk play an important role in
the nourishment of breast-fed infants and dairy consumers. Some of these ingredients …

Turbot (Scophthalmus maximus) is an economically important marine fish cultured in China.
In this study, we performed transcriptome gene expression profiling of kidney tissue in turbot …

Unlike traditional chemotherapy agents which are generally cytotoxic to all cells, targeted
anti-cancer therapies are designed to specifically target proliferation mechanisms in cancer …