Cytosolic phospholipase A2: physiological function and role in disease

CC Leslie - Journal of lipid research, 2015 - ASBMB
The group IV phospholipase A 2 (PLA 2) family is comprised of six intracellular enzymes
(GIVA,-B,-C,-D,-E, and-F) commonly referred to as cytosolic PLA 2 (cPLA 2) α,-β,-γ,-δ,-ε, and …

Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF …

YJ Surh, KS Chun, HH Cha, SS Han, YS Keum… - Mutation Research …, 2001 - Elsevier
A wide array of phenolic substances, particularly those present in edible and medicinal
plants, have been reported to possess substantial anticarcinogenic and antimutagenic …

Mechanistic links between COPD and lung cancer

AMG Houghton - Nature Reviews Cancer, 2013 - nature.com
Numerous epidemiological studies have consistently linked the presence of chronic
obstructive pulmonary disease (COPD) to the development of lung cancer, independently of …

Prostaglandins and cancer

D Wang, RN DuBois - Gut, 2006 - gut.bmj.com
Chemoprevention has been considered as a possible approach for cancer prevention. A
significant effort has been made in the development of novel drugs for both cancer …

Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response

RA Mitchell, H Liao, J Chesney… - Proceedings of the …, 2002 - National Acad Sciences
The importance of the macrophage in innate immunity is underscored by its secretion of an
array of powerful immunoregulatory and effector molecules. We report herein that …

Phospholipase A2 enzymes

I Kudo, M Murakami - Prostaglandins & other lipid mediators, 2002 - Elsevier
Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …

Mouse models for the study of colon carcinogenesis

DW Rosenberg, C Giardina, T Tanaka - Carcinogenesis, 2009 - academic.oup.com
The study of experimental colon carcinogenesis in rodents has a long history, dating back
almost 80 years. There are many advantages to studying the pathogenesis of carcinogen …

Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer

ON Tucker, AJ Dannenberg, EK Yang, F Zhang, L Teng… - Cancer research, 1999 - AACR
A large body of evidence suggests that cyclooxygenase-2 (COX-2) is important in
gastrointestinal cancer. The purpose of this study was to determine whether COX-2 was …

Phospholipase A2 superfamily in cancer

Z Peng, Y Chang, J Fan, W Ji, C Su - Cancer Letters, 2021 - Elsevier
Phospholipase A2 enzymes (PLA 2 s) comprise a superfamily that is generally divided into
six subfamilies known as cytosolic PLA 2 s (cPLA 2 s), calcium-independent PLA 2 s (iPLA 2 …

Properties of the Group IV phospholipase A2 family

M Ghosh, DE Tucker, SA Burchett, CC Leslie - Progress in lipid research, 2006 - Elsevier
The Group IV phospholipase A2 family is comprised of six intracellular enzymes commonly
called cytosolic phospholipase A2 (cPLA2) α, cPLA2β, cPLA2γ, cPLA2δ, cPLA2ε and …