The cilium is a complex organelle, the assembly of which requires the coordination of motor-
driven intraflagellar transport (IFT), membrane trafficking and selective import of cilium …

During the last two to three decades, a large body of work has revealed the molecular basis
of many human disorders, including retinal and vitreoretinal degenerations and …

Cilia are microscopic projections that extend from eukaryotic cells. There are two general
types of cilia; primary cilia serve as sensory organelles, whereas motile cilia exert …

Respect for the primary cilium has undergone a remarkable renaissance over the past
decade, and it is now thought to be an essential regulator of numerous signaling pathways …

Bardet–Biedl syndrome (BBS) is a rare inherited disease caused by defects in the BBSome,
an octameric complex of BBS proteins. The BBSome is conserved in most organisms with …

Primary cilia are generally solitary organelles that emanate from the surface of almost all
vertebrate cell types. Until recently, details regarding the function of these structures were …

Bardet-Biedl syndrome (BBS) is a human genetic disorder resulting in obesity, retinal
degeneration, polydactyly, and nephropathy. Recent studies indicate that trafficking defects …

Bardet-Biedl syndrome (BBS) is a multisystemic disorder typified by developmental and
progressive degenerative defects. A combination of genetic, in vitro, and in vivo studies have …

Humans possess the remarkable ability to perceive color, shape, and motion, and to
differentiate between light intensities varied by over nine orders of magnitude …

Sperm motility is necessary for the transport of male DNA to eggs in species with both
external and internal fertilization. Flagella comprise several proteins for generating and …