Mammalian in vitro gametogenesis
M Saitou, K Hayashi - Science, 2021 - science.org
BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …
New insights into the generation and role of de novo mutations in health and disease
Aside from inheriting half of the genome of each of our parents, we are born with a small
number of novel mutations that occurred during gametogenesis and postzygotically. Recent …
number of novel mutations that occurred during gametogenesis and postzygotically. Recent …
Parental influence on human germline de novo mutations in 1,548 trios from Iceland
The characterization of mutational processes that generate sequence diversity in the human
genome is of paramount importance both to medical genetics, and to evolutionary studies …
genome is of paramount importance both to medical genetics, and to evolutionary studies …
The Simons genome diversity project: 300 genomes from 142 diverse populations
Here we report the Simons Genome Diversity Project data set: high quality genomes from
300 individuals from 142 diverse populations. These genomes include at least 5.8 million …
300 individuals from 142 diverse populations. These genomes include at least 5.8 million …
Origins and evolution of extreme life span in Pacific Ocean rockfishes
Pacific Ocean rockfishes (genus Sebastes) exhibit extreme variation in life span, with some
species being among the most long-lived extant vertebrates. We de novo assembled the …
species being among the most long-lived extant vertebrates. We de novo assembled the …
Timing, rates and spectra of human germline mutation
R Rahbari, A Wuster, SJ Lindsay, RJ Hardwick… - Nature …, 2016 - nature.com
Germline mutations are a driving force behind genome evolution and genetic disease. We
investigated genome-wide mutation rates and spectra in multi-sibling families. The mutation …
investigated genome-wide mutation rates and spectra in multi-sibling families. The mutation …
Whole-genome sequences of Malawi cichlids reveal multiple radiations interconnected by gene flow
The hundreds of cichlid fish species in Lake Malawi constitute the most extensive recent
vertebrate adaptive radiation. Here we characterize its genomic diversity by sequencing 134 …
vertebrate adaptive radiation. Here we characterize its genomic diversity by sequencing 134 …
Evidence for archaic adaptive introgression in humans
As modern and ancient DNA sequence data from diverse human populations accumulate,
evidence is increasing in support of the existence of beneficial variants acquired from …
evidence is increasing in support of the existence of beneficial variants acquired from …
Genomic islands of speciation separate cichlid ecomorphs in an East African crater lake
The genomic causes and effects of divergent ecological selection during speciation are still
poorly understood. Here we report the discovery and detailed characterization of early-stage …
poorly understood. Here we report the discovery and detailed characterization of early-stage …
Morphometric, behavioral, and genomic evidence for a new orangutan species
Six extant species of non-human great apes are currently recognized: Sumatran and
Bornean orangutans, eastern and western gorillas, and chimpanzees and bonobos [1] …
Bornean orangutans, eastern and western gorillas, and chimpanzees and bonobos [1] …