Culture-negative early-onset neonatal sepsis—at the crossroad between efficient sepsis care and antimicrobial stewardship

C Klingenberg, RF Kornelisse, G Buonocore… - Frontiers in …, 2018 - frontiersin.org
Sepsis is a leading cause of mortality and morbidity in neonates. Presenting clinical
symptoms are unspecific. Sensitivity and positive predictive value of biomarkers at onset of …

Challenges in developing a consensus definition of neonatal sepsis

M McGovern, E Giannoni, H Kuester, MA Turner… - Pediatric …, 2020 - nature.com
Sepsis remains a leading cause of morbidity and mortality in the neonatal population, and at
present, there is no unified definition of neonatal sepsis. Existing consensus sepsis …

Neonatal sepsis

M Ershad, A Mostafa, M Dela Cruz… - Current emergency and …, 2019 - Springer
Abstract Purpose of Review Neonatal sepsis is a diagnosis made in infants less than 28
days of life and consists of a clinical syndrome that may include systemic signs of infection …

Relevance of biomarkers currently in use or research for practical diagnosis approach of neonatal early-onset sepsis

MA Hincu, GI Zonda, GD Stanciu, D Nemescu… - Children, 2020 - mdpi.com
Neonatal early-onset sepsis (EOS) is defined as an invasive infection that occurs in the first
72 h of life. The incidence of EOS varies from 0.5–2% live births in developed countries, up …

Fighting antimicrobial resistance in neonatal intensive care units: rational use of antibiotics in neonatal sepsis

D Rallis, V Giapros, A Serbis, C Kosmeri, M Baltogianni - Antibiotics, 2023 - mdpi.com
Antibiotics are the most frequently prescribed drugs in neonatal intensive care units (NICUs)
due to the severity of complications accompanying neonatal sepsis. However, antimicrobial …

How could metabolomics change pediatric health?

F Bardanzellu, V Fanos - Italian Journal of Pediatrics, 2020 - Springer
In the last years,'omics' technologies, and especially metabolomics, emerged as expanding
scientific disciplines and promising technologies in the characterization of several …

Sepsis-induced immunosuppression in neonates

JE Hibbert, A Currie, T Strunk - Frontiers in Pediatrics, 2018 - frontiersin.org
Neonates, especially those born preterm, are at increased risk of sepsis and adverse long-
term effects associated with infection-related inflammation. Distinct neonatal immune …

Association of histological and clinical chorioamnionitis with neonatal sepsis among preterm infants: a systematic review, meta-analysis, and meta-regression

E Villamor-Martinez, GA Lubach, OM Rahim… - Frontiers in …, 2020 - frontiersin.org
Chorioamnionitis (CA) is considered a key risk factor for very preterm birth and for
developing early onset sepsis (EOS) in preterm infants, but recent data suggest that CA …

miRNA-23b as a biomarker of culture-positive neonatal sepsis

A Fatmi, SA Rebiahi, N Chabni, H Zerrouki… - Molecular …, 2020 - Springer
Background Neonatal sepsis remains an important cause of morbidity and mortality. The
ability to quickly and accurately diagnose neonatal sepsis based on clinical assessments …

Molecular methodologies for improved polymicrobial sepsis diagnosis

M Doualeh, M Payne, E Litton, E Raby… - International Journal of …, 2022 - mdpi.com
Polymicrobial sepsis is associated with worse patient outcomes than monomicrobial sepsis.
Routinely used culture-dependent microbiological diagnostic techniques have low …