New insights into the ambivalent role of YAP/TAZ in human cancers
J Luo, L Deng, H Zou, Y Guo, T Tong, M Huang… - Journal of Experimental …, 2023 - Springer
Hippo signaling was first identified in Drosophila as a key controller of organ size by
regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this …
regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this …
Context-dependent roles of YAP/TAZ in stem cell fates and cancer
Hippo effectors YAP and TAZ control cell fate and survival through various mechanisms,
including transcriptional regulation of key genes. However, much of this research has been …
including transcriptional regulation of key genes. However, much of this research has been …
Emerging Principles in the Transcriptional Control by YAP and TAZ
A Lopez-Hernandez, S Sberna, S Campaner - Cancers, 2021 - mdpi.com
Simple Summary YAP and TAZ are transcriptional cofactors that integrate several upstream
signals to generate context-dependent transcriptional responses. This requires extensive …
signals to generate context-dependent transcriptional responses. This requires extensive …
The multiple interactions of RUNX with the Hippo–YAP pathway
LSH Chuang, Y Ito - Cells, 2021 - mdpi.com
The Hippo–YAP signaling pathway serves roles in cell proliferation, stem cell
renewal/maintenance, differentiation and apoptosis. Many of its functions are central to early …
renewal/maintenance, differentiation and apoptosis. Many of its functions are central to early …
YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma
Background Merkel cell carcinoma (MCC) is an aggressive neuroendocrine (NE) skin
cancer caused by severe UV-induced mutations or expression of Merkel cell polyomavirus …
cancer caused by severe UV-induced mutations or expression of Merkel cell polyomavirus …
The new world of RNA diagnostics and therapeutics
G Blandino, R Dinami, M Marcia… - Journal of Experimental …, 2023 - Springer
The 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27–28 March
at the IRCCS Regina Elena National Cancer Institute. This meeting entitled “The New World …
at the IRCCS Regina Elena National Cancer Institute. This meeting entitled “The New World …
[HTML][HTML] Liquid‒liquid phase separation: roles and implications in future cancer treatment
Z Liu, Z Qin, Y Liu, X Xia, L He, N Chen… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Liquid‒liquid phase separation (LLPS) is a phenomenon driven by weak interactions
between biomolecules, such as proteins and nucleic acids, that leads to the formation of …
between biomolecules, such as proteins and nucleic acids, that leads to the formation of …
The Hippo pathway transcription factors YAP and TAZ play HPV-type dependent roles in cervical cancer
MR Patterson, JA Cogan, R Cassidy… - Nature …, 2024 - nature.com
Human papillomaviruses (HPVs) cause most cervical cancers and an increasing number of
anogenital and oral carcinomas, with most cases caused by HPV16 or HPV18. HPV hijacks …
anogenital and oral carcinomas, with most cases caused by HPV16 or HPV18. HPV hijacks …
[HTML][HTML] MYC inhibitors in multiple myeloma
S Martínez-Martín, L Soucek - Cancer Drug Resistance, 2021 - ncbi.nlm.nih.gov
The importance of MYC function in cancer was discovered in the late 1970s when the
sequence of the avian retrovirus that causes myelocytic leukemia was identified. Since then …
sequence of the avian retrovirus that causes myelocytic leukemia was identified. Since then …
Unraveling the biology of epithelioid hemangioendothelioma, a TAZ–CAMTA1 fusion driven sarcoma
Simple Summary Epithelioid hemangioendothelioma (EHE) is a rare vascular cancer that
involves a gain-of-function gene fusion involving TAZ, a transcriptional coactivator, and one …
involves a gain-of-function gene fusion involving TAZ, a transcriptional coactivator, and one …