Hippo signaling was first identified in Drosophila as a key controller of organ size by
regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this …

Hippo effectors YAP and TAZ control cell fate and survival through various mechanisms,
including transcriptional regulation of key genes. However, much of this research has been …

Simple Summary YAP and TAZ are transcriptional cofactors that integrate several upstream
signals to generate context-dependent transcriptional responses. This requires extensive …

The Hippo–YAP signaling pathway serves roles in cell proliferation, stem cell
renewal/maintenance, differentiation and apoptosis. Many of its functions are central to early …

Background Merkel cell carcinoma (MCC) is an aggressive neuroendocrine (NE) skin
cancer caused by severe UV-induced mutations or expression of Merkel cell polyomavirus …

The 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27–28 March
at the IRCCS Regina Elena National Cancer Institute. This meeting entitled “The New World …

Liquid‒liquid phase separation (LLPS) is a phenomenon driven by weak interactions
between biomolecules, such as proteins and nucleic acids, that leads to the formation of …

Human papillomaviruses (HPVs) cause most cervical cancers and an increasing number of
anogenital and oral carcinomas, with most cases caused by HPV16 or HPV18. HPV hijacks …

The importance of MYC function in cancer was discovered in the late 1970s when the
sequence of the avian retrovirus that causes myelocytic leukemia was identified. Since then …

Simple Summary Epithelioid hemangioendothelioma (EHE) is a rare vascular cancer that
involves a gain-of-function gene fusion involving TAZ, a transcriptional coactivator, and one …