While spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which
are life threatening, the majority of SCIs are anatomically incomplete. Spared neural …

Neuromuscular impairment and reduced musculoskeletal integrity are hallmarks of spinal
cord injury (SCI) that hinder locomotor recovery. These impairments are precipitated by the …

Midcervical spinal cord contusion injury results in tissue damage, disruption of spinal
pathways, and motor neuron loss. Unilateral C4 contusion results in loss of 40%–50% of …

Unilateral C2 hemisection (C2SH) disrupts descending inspiratory-related drive to phrenic
motor neurons and thus, silences rhythmic diaphragm muscle (DIAm) activity. There is …

We developed an innovative biomaterial-based approach to repair the critical neural
circuitry that controls diaphragm activation by locally delivering brain-derived neurotrophic …

Unilateral C2 cervical spinal cord hemisection (SH) disrupts descending excitatory drive to
phrenic motor neurons, thereby paralyzing the ipsilateral diaphragm muscle (DIAm) during …

Spinal cord injury (SCI) is a neurodegenerative disorder that has critical impact on patient's
life expectance and life span, and this disorder also leads to negative socioeconomic …

Abstract Activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors increases phrenic motor output. Ampakines are a class of drugs that are positive …

Neuropathic pain (NP) following spinal cord injury (SCI) often lasts for a long time and
causes a range of problems that reduce the quality of life. Current treatments are not …

Impaired respiratory function is a common and devastating consequence of cervical spinal
cord injury. Accordingly, the development of safe and effective treatments to restore …