As one of the most common tumors in women, the pathogenesis and tumor heterogeneity of
breast cancer have long been the focal point of research, with the emergence of tumor …

The androgen receptor (AR) signalling pathway has been intensively studied in the context
of prostate cancer, where androgen deprivation therapy is part of the standard of care for …

Senescent cells can either to promote immunosuppressive tumor microenvironment or
facilitate immune surveillance. Despite the revolutionary impact of cancer immunotherapy …

Aging is the greatest risk factor for breast cancer; however, how age-related cellular and
molecular events impact cancer initiation is unknown. In this study, we investigated how …

Lung cancer is a fatal complication of idiopathic pulmonary fibrosis (IPF) with a poor
prognosis. Current treatments are insufficient in improving the prognosis of lung cancer …

Cellular senescence is closely associated with cancer development and progression. There
is ample evidence that tumor stromal cells, especially cancer-associated fibroblasts (CAFs) …

Cancer-associated fibroblasts (CAFs) are abundant components of the tumor
microenvironment (TME) of most solid malignancies and have emerged as key regulators of …

Aging is associated with stereotyped changes in the tissue microenvironment that increase
susceptibility to diseases of the elderly, including organ fibrosis and cancer. From a tissue …

Chronic damage following oncogene induction or cancer therapy can produce cellular
senescence. Senescent cells not only exit the cell cycle but communicate damage signals to …

Cellular senescence is a state of permanent proliferative arrest that occurs in response to
DNA damage-inducing endogenous and exogenous stresses, and is often accompanied by …