Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products

P Pandi, R Bulusu, N Kommineni, W Khan… - International journal of …, 2020 - Elsevier
Amorphous solid dispersions (ASDs) are being employed frequently to improve
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …

Structural modification aimed for improving solubility of lead compounds in early phase drug discovery

B Das, ATK Baidya, AT Mathew, AK Yadav… - Bioorganic & Medicinal …, 2022 - Elsevier
Many lead compounds fail to reach clinical trials despite being potent because of low
bioavailability attributed to their insufficient solubility making solubility a primary and crucial …

Preparation of a novel biodegradable packaging film based on corn starch-chitosan and poloxamers

A Fonseca-García, EJ Jiménez-Regalado… - Carbohydrate …, 2021 - Elsevier
Starch is an excellent alternative to produce packaging materials, however, due to its high
hydrophilicity, it is necessary to mix it with other polymers. Chitosan (CTS) is a polymer …

[HTML][HTML] Miscibility study of thermoplastic starch/polylactic acid blends: thermal and superficial properties

A Fonseca-García, BH Osorio, RY Aguirre-Loredo… - Carbohydrate …, 2022 - Elsevier
In this work, the miscibility of blends of thermoplastic Achira Starch (AS) and polylactic acid
(PLA) was evaluated, assisted by Pluronic® F127 an amphiphilic triblock copolymer that …

A simple electrochemical detection of atorvastatin based on disposable screen-printed carbon electrodes modified by molecularly imprinted polymer: Experiment and …

P Rebelo, JG Pacheco, IV Voroshylova, A Melo… - Analytica Chimica …, 2022 - Elsevier
Atorvastatin (ATV) is a statin member consumed in high quantities worldwide. In response to
that, the occurrence of ATV in environmental waters has become a reality, highlighting the …

A novel sustained anti-inflammatory effect of atorvastatin—calcium PLGA nanoparticles: in vitro optimization and in vivo evaluation

DH Abdelkader, AK Abosalha, MA Khattab… - Pharmaceutics, 2021 - mdpi.com
Atorvastatin Calcium (At-Ca) has pleiotropic effect as anti-inflammatory drug beside its main
antihyperlipidemic action. Our study was conducted to modulate the anti-inflammatory effect …

Tissue engineering and targeted drug delivery in cardiovascular disease: the role of polymer nanocarrier for statin therapy

N Montelione, F Loreni, A Nenna, V Catanese, L Scurto… - Biomedicines, 2023 - mdpi.com
Atherosclerosis-related coronary artery disease (CAD) is the leading cause of mortality and
morbidity worldwide. This requires effective primary and secondary prevention in reducing …

Transparent silk fibroin film-facilitated infected-wound healing through antibacterial, improved fibroblast adhesion and immune modulation

J Zhang, L Wang, C Xu, Y Cao, S Liu… - Journal of Materials …, 2024 - pubs.rsc.org
The clinical application of regenerated silk fibroin (RSF) films for wound treatment is
restricted by its undesirable mechanical properties and lack of antibacterial activity. Herein …

Glucose oxidase loaded thermosensitive hydrogel as an antibacterial wound dressing

X Fang, Y Liu, M Zhang, S Zhou, P Cui, H Hu… - Journal of Drug Delivery …, 2022 - Elsevier
Skin infection is a worldwide issue that requires joint efforts to develop suitable wound
dressing. Hydrogel as the ideal form of wound dressing usually suffered from complicated …

Polymers and nanoparticles for statin delivery: current use and future perspectives in cardiovascular disease

A Nenna, F Nappi, D Larobina, E Verghi, M Chello… - Polymers, 2021 - mdpi.com
Atherosclerosis-related coronary artery disease (CAD) is one of the leading sources of
mortality and morbidity in the world. Primary and secondary prevention appear crucial to …