Neuroinflammation and oxidative stress in the pathogenesis of autism spectrum disorder

N Usui, H Kobayashi, S Shimada - International Journal of Molecular …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) characterized by
impairments in social communication, repetitive behaviors, restricted interests, and …

Noteworthy perspectives on microglia in neuropsychiatric disorders

H Zhu, A Guan, J Liu, L Peng, Z Zhang… - Journal of …, 2023 - Springer
Microglia are so versatile that they not only provide immune surveillance for central nervous
system, but participate in neural circuitry development, brain blood vessels formation, blood …

Role of Microglia in Central Nervous System Development and Plasticity

DP Schafer, B Stevens… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
The nervous system comprises a remarkably diverse and complex network of cell types,
which must communicate with one another with speed, reliability, and precision. Thus, the …

Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury

Y Lan, X Zhang, S Liu, C Guo, Y Jin, H Li, L Wang… - Immunity, 2024 - cell.com
Microglial reactivity to injury and disease is emerging as a heterogeneous, dynamic, and
crucial determinant in neurological disorders. However, the plasticity and fate of disease …

Modeling psychotic disorders: Environment x environment interaction

K Murlanova, MV Pletnikov - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Schizophrenia is a major psychotic disorder with multifactorial etiology that includes
interactions between genetic vulnerability and environmental risk factors. In addition …

On developmental programming of the immune system

JY Hong, R Medzhitov - Trends in Immunology, 2023 - cell.com
Early-life environmental exposures play a significant role in shaping long-lasting immune
phenotypes and disease susceptibility. Nevertheless, comprehensive understanding of the …

Microbial modulation via cross-fostering prevents the effects of pervasive environmental stressors on microglia and social behavior, but not the dopamine system

CJ Smith, DN Rendina, MA Kingsbury… - Molecular …, 2023 - nature.com
Environmental toxicant exposure, including air pollution, is increasing worldwide. However,
toxicant exposures are not equitably distributed. Rather, low-income and minority …

The role of microglia in early neurodevelopment and the effects of maternal immune activation

LJM Mastenbroek, SM Kooistra, BJL Eggen… - Seminars in …, 2024 - Springer
Activation of the maternal immune system during gestation has been associated with an
increased risk for neurodevelopmental disorders in the offspring, particularly schizophrenia …

[HTML][HTML] Maternal BPAF exposure impaired synaptic development and caused behavior abnormality in offspring

X Wu, S Li, Y Ni, C Qi, S Bai, Q Xu, Y Fan, X Ma… - Ecotoxicology and …, 2023 - Elsevier
Bisphenol A (BPA) has been widely restricted, leading to a significant increase in the
production of bisphenol AF (BPAF), one of the most common bisphenol analogs use as a …

SSRI treatment modifies the effects of maternal inflammation on in utero physiology and offspring neurobiology

KE Zengeler, DA Shapiro, KR Bruch… - Brain, behavior, and …, 2023 - Elsevier
Perturbations to the in utero environment can dramatically change the trajectory of offspring
neurodevelopment. Insults commonly encountered in modern human life such as infection …