Platelets have long been recognized as key players in hemostasis and thrombosis;
however, growing evidence suggests that they are also significantly involved in cancer, the …

Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

Immune thrombocytopenia (ITP) is a common bleeding disorder caused primarily by
autoantibodies against platelet GPIIbIIIa and/or the GPIb complex. Current theory suggests …

Platelets are small anucleate cells generated from megakaryocytes in the bone marrow.
Although platelet generation, maturation, and clearance are still not fully understood …

Platelets, small anucleate cells circulating in the blood, are critical mediators in haemostasis
and thrombosis. Interestingly, recent studies demonstrated that platelets contain both pro …

Circulating platelets roll along exposed collagen at vessel injury sites and respond with
filipodia protrusion, shape change, and surface area expansion to facilitate platelet …

Platelets are central mediators of thrombosis and hemostasis. At the site of vascular injury,
platelet accumulation (ie adhesion and aggregation) constitutes the first wave of hemostasis …

Plasma fibronectin (pFn) has long been suspected to be involved in hemostasis; however,
direct evidence has been lacking. Here, we demonstrated that pFn is vital to control bleeding …

Glycoprotein VI, a major platelet activation receptor for collagen and fibrin, is considered a
particularly promising, safe antithrombotic target. In this study, we show that human …

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease characterized by
systemic microvascular thrombosis caused by adhesion of platelets to ultra-large vWF …