Context.—Chordomas are uncommon malignant neoplasms with notochordal differentiation
encountered by neuropathologists, bone/soft tissue pathologists, and general surgical …

Sarcomas represent a distinct group of rare malignant tumors with high heterogeneity.
Limited options with clinical efficacy for the metastatic or local advanced sarcoma existed …

Chordomas are rare tumors of notochord remnants, occurring mainly in the sacrum and skull
base. Despite of their unusually slow growth, chordomas are highly invasive and the …

Objective chordomas are rare bone tumors with few therapeutic options. Skull base and
sacrum are the two most common origin sites. Immunotherapies are emerging as the most …

Chordomas are malignant bone tumors that arise from remnants of the notochord. These
tumors are generally slow-growing, locally aggressive, and invasive. Chordomas are …

De‐differentiated chordoma is defined as a high‐grade sarcoma lacking notochordal
differentiation, which arises in association with conventional chordoma. The mechanism …

Background Chordoma is a slow-growing but malignant subtype of bone sarcoma with
relatively high recurrence rates and high resistance to chemotherapy. It is urgent to …

The development of effective and personalized treatment options for patients with rare
cancers like chordoma is hampered by numerous challenges. Biomarker-guided …

Introduction Chordoma is a rare slow-growing tumor that occurs along the length of the
spinal axis and arises from primitive notochordal remnants (Stepanek et al., Am J Med Genet …

Simple Summary Some locally advanced pelvic bone tumors are deemed unresectable and,
as such, not suitable for curative surgery. In this setting, treatment options are generally …