Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

Advances in nano-and microscale NMR spectroscopy using diamond quantum sensors

RD Allert, KD Briegel, DB Bucher - Chemical Communications, 2022 - pubs.rsc.org
Quantum technologies have seen a rapid developmental surge over the last couple of years.
Though often overshadowed by quantum computation, quantum sensors show tremendous …

In Vivo Metabolic Imaging of [1‐13C]Pyruvate‐d3 Hyperpolarized By Reversible Exchange With Parahydrogen**

H de Maissin, PR Groß, O Mohiuddin… - Angewandte Chemie …, 2023 - Wiley Online Library
Metabolic magnetic resonance imaging (MRI) using hyperpolarized (HP) pyruvate is
becoming a non‐invasive technique for diagnosing, staging, and monitoring response to …

Catalyst-Free Aqueous Hyperpolarized [1-13C]Pyruvate Obtained by Re-Dissolution Signal Amplification by Reversible Exchange

AB Schmidt, H de Maissin, I Adelabu, S Nantogma… - ACS …, 2022 - ACS Publications
Despite great successes in oncology, patient outcomes are often still discouraging, and
hence the diagnostic imaging paradigm is increasingly shifting toward functional imaging of …

Instrumentation for hydrogenative parahydrogen-based hyperpolarization techniques

AB Schmidt, CR Bowers, K Buckenmaier… - Analytical …, 2022 - ACS Publications
The unique properties of the entangled, antisymmetric nuclear spin state of dihydrogen,
parahydrogen (pH2), has intrigued physicists, chemists, and other scientists for almost a …

Temperature Cycling Enables Efficient 13C SABRE-SHEATH Hyperpolarization and Imaging of [1-13C]-Pyruvate

P TomHon, M Abdulmojeed, I Adelabu… - Journal of the …, 2021 - ACS Publications
Molecular metabolic imaging in humans is dominated by positron emission tomography
(PET). An emerging nonionizing alternative is hyperpolarized MRI of 13C-pyruvate, which is …

Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution

S Knecht, JW Blanchard, D Barskiy… - Proceedings of the …, 2021 - National Acad Sciences
Hyperpolarized fumarate is a promising biosensor for carbon-13 magnetic resonance
metabolic imaging. Such molecular imaging applications require nuclear hyperpolarization …

Hyperpolarising pyruvate through signal amplification by reversible exchange (SABRE)

W Iali, SS Roy, BJ Tickner, F Ahwal… - Angewandte …, 2019 - Wiley Online Library
Hyperpolarisation methods that premagnetise agents such as pyruvate are currently
receiving significant attention because they produce sensitivity gains that allow disease …

Recent advances in the application of parahydrogen in catalysis and biochemistry

G Buntkowsky, F Theiss, J Lins, YA Miloslavina… - RSC …, 2022 - pubs.rsc.org
Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI)
are analytical and diagnostic tools that are essential for a very broad field of applications …

Order‐Unity 13C Nuclear Polarization of [1‐13C]Pyruvate in Seconds and the Interplay of Water and SABRE Enhancement

I Adelabu, P TomHon, MSH Kabir… - …, 2022 - Wiley Online Library
Abstract Signal Amplification By Reversible Exchange in SHield Enabled Alignment Transfer
(SABRE‐SHEATH) is investigated to achieve rapid hyperpolarization of 13C1 spins of [1 …