The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review
ESE Mehana, AF Khafaga, SS El-Blehi - Life sciences, 2019 - Elsevier
Extensive degeneration of articular cartilage (AC) is a primary event in the pathogenesis of
osteoarthritis (OA) and other types of joint and bone inflammation. OA results in the loss of …
osteoarthritis (OA) and other types of joint and bone inflammation. OA results in the loss of …
[HTML][HTML] Matrix metalloproteinases participation in the metastatic process and their diagnostic and therapeutic applications in cancer
G Gonzalez-Avila, B Sommer… - Critical reviews in …, 2019 - Elsevier
Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …
settlement of a metastatic niche in a second organ. Their role in cancer progression is …
Metalloproteinases and their inhibitors: potential for the development of new therapeutics
M Raeeszadeh-Sarmazdeh, LD Do, BG Hritz - Cells, 2020 - mdpi.com
The metalloproteinase (MP) family of zinc-dependent proteases, including matrix
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …
Lung cancers: molecular characterization, clonal heterogeneity and evolution, and cancer stem cells
U Testa, G Castelli, E Pelosi - Cancers, 2018 - mdpi.com
Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …
Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment
J López de Andrés, C Griñán-Lisón, G Jiménez… - Journal of hematology & …, 2020 - Springer
Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis
and resistance to chemo-and radiotherapy, ultimately leading to tumor relapse. As a …
and resistance to chemo-and radiotherapy, ultimately leading to tumor relapse. As a …
Cellular and extracellular components in tumor microenvironment and their application in early diagnosis of cancers
R Wei, S Liu, S Zhang, L Min… - Analytical Cellular …, 2020 - Wiley Online Library
Tumors are surrounded by complex environmental components, including blood and lymph
vessels, fibroblasts, endothelial cells, immune cells, cytokines, extracellular vesicles, and …
vessels, fibroblasts, endothelial cells, immune cells, cytokines, extracellular vesicles, and …
Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer
A Schmall, HM Al-Tamari, S Herold… - American journal of …, 2015 - atsjournals.org
Rationale: Recent studies indicate that tumor-associated macrophages (MΦ) with an M2
phenotype can influence cancer progression and metastasis, but the regulatory pathways …
phenotype can influence cancer progression and metastasis, but the regulatory pathways …
[HTML][HTML] The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma
V Justilien, MP Walsh, SA Ali, EA Thompson… - Cancer cell, 2014 - cell.com
We report that two oncogenes coamplified on chromosome 3q26, PRKCI and SOX2,
cooperate to drive a stem-like phenotype in lung squamous cell carcinoma (LSCC). Protein …
cooperate to drive a stem-like phenotype in lung squamous cell carcinoma (LSCC). Protein …
The tumor microenvironment regulates sensitivity of murine lung tumors to PD-1/PD-L1 antibody blockade
HY Li, M McSharry, B Bullock, TT Nguyen, J Kwak… - Cancer immunology …, 2017 - AACR
Immune checkpoint inhibitors targeting the interaction between programmed cell death-1
(PD-1) and its ligand PD-L1 induce tumor regression in a subset of non–small cell lung …
(PD-1) and its ligand PD-L1 induce tumor regression in a subset of non–small cell lung …
The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment
Despite recent progresses in tumor therapy and increased knowledge in tumor biology,
tumor remains a common and lethal disease worldwide. Cancer stem cells (CSCs) are a …
tumor remains a common and lethal disease worldwide. Cancer stem cells (CSCs) are a …