Extensive degeneration of articular cartilage (AC) is a primary event in the pathogenesis of
osteoarthritis (OA) and other types of joint and bone inflammation. OA results in the loss of …

Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

The metalloproteinase (MP) family of zinc-dependent proteases, including matrix
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …

Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis
and resistance to chemo-and radiotherapy, ultimately leading to tumor relapse. As a …

Tumors are surrounded by complex environmental components, including blood and lymph
vessels, fibroblasts, endothelial cells, immune cells, cytokines, extracellular vesicles, and …

Rationale: Recent studies indicate that tumor-associated macrophages (MΦ) with an M2
phenotype can influence cancer progression and metastasis, but the regulatory pathways …

We report that two oncogenes coamplified on chromosome 3q26, PRKCI and SOX2,
cooperate to drive a stem-like phenotype in lung squamous cell carcinoma (LSCC). Protein …

Immune checkpoint inhibitors targeting the interaction between programmed cell death-1
(PD-1) and its ligand PD-L1 induce tumor regression in a subset of non–small cell lung …

Despite recent progresses in tumor therapy and increased knowledge in tumor biology,
tumor remains a common and lethal disease worldwide. Cancer stem cells (CSCs) are a …