Female and male rats readily consume and prefer oxycodone to water in a chronic, continuous access, two-bottle oral voluntary paradigm
G Zanni, MJ DeSalle, HM Deutsch, GA Barr… - Neuropharmacology, 2020 - Elsevier
The increasing abuse of opioids-such as oxycodone-poses major challenges for health and
socioeconomic systems. Human prescription opioid abuse is marked by chronic, voluntary …
socioeconomic systems. Human prescription opioid abuse is marked by chronic, voluntary …
[HTML][HTML] Attenuation of the Infiltration of Angiotensin II Expressing CD3+ T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia – A Possible …
Recent preclinical and proof-of-concept clinical studies have shown promising analgesic
efficacy of selective small molecule angiotensin II type 2 (AT2) receptor antagonists in the …
efficacy of selective small molecule angiotensin II type 2 (AT2) receptor antagonists in the …
[HTML][HTML] Local injury and systemic infection in infants alter later nociception and pain affect during early life and adulthood
CI Gomes, GA Barr - Brain, Behavior, & Immunity-Health, 2020 - Elsevier
Newborns in intensive care are regularly exposed to minor painful procedures at
developmental time points when noxious stimulation would be normally absent. Pain from …
developmental time points when noxious stimulation would be normally absent. Pain from …
[HTML][HTML] Current Evidence for Biological Biomarkers and Mechanisms Underlying Acute to Chronic Pain Transition across the Pediatric Age Spectrum
IT Duff, KN Krolick, HM Mahmoud… - Journal of Clinical …, 2023 - mdpi.com
Chronic pain is highly prevalent in the pediatric population. Many factors are involved in the
transition from acute to chronic pain. Currently, there are conceptual models proposed, but …
transition from acute to chronic pain. Currently, there are conceptual models proposed, but …
Maternal continuous oral oxycodone self-administration alters pup affective/social communication but not spatial learning or sensory-motor function
G Zanni, PA Robinson-Drummer, AA Dougher… - Drug and alcohol …, 2021 - Elsevier
Background The broad use/misuse of prescription opioids during pregnancy has resulted in
a surge of infants with Neonatal Opioid Withdrawal Syndrome (NOWS). Short-term irritability …
a surge of infants with Neonatal Opioid Withdrawal Syndrome (NOWS). Short-term irritability …
[HTML][HTML] NO-cGMP-K channel-dependent anti-nociceptive activities of methanol stem bark extract of Piptadeniastrum africanum (Mimosaceae) on rats
Objective: To explore anti-hyperalgesic properties of methanol extract of Piptadeniastrum
africanum stem bark (PAME) and it possible action mechanism. Methods: PAME was tested …
africanum stem bark (PAME) and it possible action mechanism. Methods: PAME was tested …
Female rats consume and prefer oxycodone more than males in a chronic two-bottle oral voluntary choice paradigm
The increased abuse of opioids-such as oxycodone-poses major challenges for health and
socioeconomic systems. Human prescription opioid abuse is marked by continuous …
socioeconomic systems. Human prescription opioid abuse is marked by continuous …