Ethnobotany and the role of plant natural products in antibiotic drug discovery

G Porras, F Chassagne, JT Lyles, L Marquez… - Chemical …, 2020 - ACS Publications
The crisis of antibiotic resistance necessitates creative and innovative approaches, from
chemical identification and analysis to the assessment of bioactivity. Plant natural products …

Natural products against key Mycobacterium tuberculosis enzymatic targets: Emerging opportunities for drug discovery

G Cazzaniga, M Mori, LR Chiarelli, A Gelain… - European journal of …, 2021 - Elsevier
For centuries, natural products (NPs) have served as powerful therapeutics against a variety
of human ailments. Nowadays, they still represent invaluable resources for the treatment of …

Bactericidal Activity of Larrea tridentata Hydroalcoholic Extract against Phytopathogenic Bacteria

AL Morales-Ubaldo, N Rivero-Perez, F Avila-Ramos… - Agronomy, 2021 - mdpi.com
Due to the emergence of bacterial resistance in phytopathogenic microorganisms, it is
necessary to search for new treatment alternatives for these pathogens. Natural extracts are …

Phytochemical Compounds and Pharmacological Properties of Larrea tridentata

AL Morales-Ubaldo, N Rivero-Perez… - Molecules, 2022 - mdpi.com
For centuries, traditional medicine from plants (phytotherapy) was the only treatment for
infectious and non-infectious diseases. Although it is still practiced in several countries with …

nor 3′-Demethoxyisoguaiacin from Larrea tridentata Is a Potential Alternative against Multidrug-Resistant Bacteria Associated with Bovine Mastitis

AL Morales-Ubaldo, M Gonzalez-Cortazar… - Molecules, 2022 - mdpi.com
Bovine mastitis is one of the most common diseases in dairy cows, and it causes significant
economic losses in dairy industries worldwide. Gram-positive and Gram-negative bacteria …

[HTML][HTML] Nordihydroguaiaretic acid (NDGA) and α-mangostin inhibit the growth of Mycobacterium tuberculosis by inducing autophagy

S Guzmán-Beltrán, MÁ Rubio-Badillo, E Juárez… - International …, 2016 - Elsevier
Tuberculosis (TB) remains as a global health problem. The prevalence of this infection is
related to the association with other diseases, such as HIV, neglect treatment and misuse of …

Context-specific metabolic network reconstruction of a naphthalene-degrading bacterial community guided by metaproteomic data

L Tobalina, R Bargiela, J Pey, FA Herbst, I Lores… - …, 2015 - academic.oup.com
Motivation: With the advent of meta-'omics' data, the use of metabolic networks for the
functional analysis of microbial communities became possible. However, while network …

New cyclolignans of Larrea tridentata and their antibacterial and cytotoxic activities

G Núñez-Mojica, AL Vázquez-Ramírez, A García… - Phytochemistry …, 2021 - Elsevier
From the chloroform extract of Larrea tridentata (Ses. et Moc ex DC.) Coville two new
cyclolignans (1 and 2) and six known compounds (3–8) were isolated and characterized …

Antimycobacterial mechanism of vanillin involves disruption of cell-surface integrity, virulence attributes, and iron homeostasis

S Sharma, R Pal, S Hameed… - The International Journal of …, 2016 - journals.lww.com
Methods: Drug susceptibilities were performed using broth microdilution, spot, and filter-disc
assays. Membrane damage was studied by nitrocefin hydrolysis and electron microscopy …

meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity

K Reyes-Melo, A García, A Romo-Mancillas… - Bioorganic & Medicinal …, 2017 - Elsevier
Thirty-three meso-dihydroguaiaretic acid (meso-DGA) derivatives bearing esters, ethers,
and amino-ethers were synthesized. All derivatives were tested against twelve drug …