Challenges in the use of animal models and perspectives for a translational view of stress and psychopathologies

NCB Barroca, G Della Santa, D Suchecki… - Neuroscience & …, 2022 - Elsevier
The neurobiology and development of treatments for stress-related neuropsychiatric
disorders rely heavily on animal models. However, the complexity of these disorders makes …

Anti-anxiety properties of selected medicinal plants

A Khan, M Akram, M Thiruvengadam… - Current …, 2022 - ingentaconnect.com
Exploration of new drugs targeting anxiety treatment is a major concern worldwide.
Medicinal plants are being used as a potential source of novel drugs for anxiety disorders …

CB1 receptor signalling mediates cannabidiol-induced panicolytic-like effects and defensive antinociception impairment in mice threatened by Bothrops jararaca …

BM de Paula Rodrigues… - Journal of …, 2022 - journals.sagepub.com
Background: Cannabis sativa-derived substances such as cannabidiol (CBD) have attracted
increasing clinical interest and consist in a new perspective for treating some neurological …

Defensive behaviors and brain regional activation changes in rats confronting a snake

J Mendes-Gomes, SC Motta, RP Bindi… - Behavioural Brain …, 2020 - Elsevier
In the present study, we examined behavioral and brain regional activation changes of rats).
To a nonmammalian predator, a wild rattler snake (Crotalus durissus terrificus). Accordingly …

Delivery of graphene oxide nanosheets modulates glutamate release and normalizes amygdala synaptic plasticity to improve anxiety-related behavior

E Pati, AF Biagioni, R Casani, N Lozano, K Kostarelos… - Nanoscale, 2023 - pubs.rsc.org
Graphene oxide nanosheets (GO) were reported to alter neurobiological processes
involving cell membrane dynamics. GO ability to reversibly downregulate specifically …

The rodent-versus-wild snake paradigm as a model for studying anxiety-and panic-like behaviors: face, construct and predictive validities

T Paschoalin-Maurin, T dos Anjos-Garcia… - Neuroscience, 2018 - Elsevier
Using an innovative approach to study the neural bases of psychiatric disorders, this study
investigated the behavioral, morphological and pharmacological bases of panic attack …

[HTML][HTML] Graphene oxide prevents lateral amygdala dysfunctional synaptic plasticity and reverts long lasting anxiety behavior in rats

AF Biagioni, G Cellot, E Pati, N Lozano, B Ballesteros… - Biomaterials, 2021 - Elsevier
Engineered small graphene oxide (s-GO) sheets were previously shown to reversibly down-
regulate glutamatergic synapses in the hippocampus of juvenile rats, disclosing an …

Investigating the effect of parental pre-gestational stress on ethological parameters in male rat offspring

N Azizi, M Heidari, E Saboory, N Abdollahzade… - Journal of Veterinary …, 2024 - Elsevier
Although extensive research has focused on the impact of maternal stress during
pregnancy, there remains a significant gap in understanding the influence of pre-pregnancy …

Opioid neurotransmission modulates defensive behavior and fear-induced antinociception in dangerous environments

NC Coimbra, F Calvo, RC Almada, RL Freitas… - Neuroscience, 2017 - Elsevier
The effects of endogenous opioid peptide antagonists on panic-related responses are
controversial. Using elevated mazes and a prey-versus-predator paradigm, we investigated …

Reduced perineuronal net expression in Fmr1 KO mice auditory cortex and amygdala is linked to impaired fear-associated memory

SM Reinhard, M Rais, S Afroz, Y Hanania… - Neurobiology of learning …, 2019 - Elsevier
Abstract Fragile X Syndrome (FXS) is a leading cause of heritable intellectual disability and
autism. Humans with FXS show anxiety, sensory hypersensitivity and impaired learning. The …