The role of the cytoskeleton in sensing changes in gravity by nonspecialized cells

D Vorselen, WH Roos, FC MacKintosh… - The FASEB …, 2014 - Wiley Online Library
A large body of evidence indicates that single cells in vitro respond to changes in gravity,
and that this response might play an important role for physiological changes at the …

Growing tissues in real and simulated microgravity: new methods for tissue engineering

D Grimm, M Wehland, J Pietsch… - … Engineering Part B …, 2014 - liebertpub.com
Tissue engineering in simulated (s-) and real microgravity (r-μ g) is currently a topic in Space
medicine contributing to biomedical sciences and their applications on Earth. The principal …

The impact of microgravity and hypergravity on endothelial cells

JAM Maier, F Cialdai, M Monici… - BioMed research …, 2015 - Wiley Online Library
The endothelial cells (ECs), which line the inner surface of vessels, play a fundamental role
in maintaining vascular integrity and tissue homeostasis, since they regulate local blood flow …

Real microgravity influences the cytoskeleton and focal adhesions in human breast cancer cells

MZ Nassef, S Kopp, M Wehland, D Melnik… - International journal of …, 2019 - mdpi.com
With the increasing number of spaceflights, it is crucial to understand the changes occurring
in human cells exposed to real microgravity (r-µ g) conditions. We tested the effect of r-µ g on …

Alterations of the cytoskeleton in human cells in space proved by life-cell imaging

TJ Corydon, S Kopp, M Wehland, M Braun, A Schütte… - Scientific reports, 2016 - nature.com
Microgravity induces changes in the cytoskeleton. This might have an impact on cells and
organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity …

The challenging environment on board the International Space Station affects endothelial cell function by triggering oxidative stress through thioredoxin interacting …

S Versari, G Longinotti, L Barenghi… - The FASEB …, 2013 - Wiley Online Library
Exposure to microgravity generates alterations that are similar to those involved in age‐
related diseases, such as cardiovascular deconditioning, bone loss, muscle atrophy, and …

Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space

X Ma, J Pietsch, M Wehland, H Schulz… - The FASEB …, 2014 - Wiley Online Library
This study focuses on the effects of short‐term [22 s, parabolic flight campaign (PFC)] and
long‐term (10 d, Shenzhou 8 space mission) real microgravity on changes in cytokine …

The impact of simulated and real microgravity on bone cells and mesenchymal stem cells

C Ulbrich, M Wehland, J Pietsch… - BioMed research …, 2014 - Wiley Online Library
How microgravity affects the biology of human cells and the formation of 3D cell cultures in
real and simulated microgravity (r‐and s‐µg) is currently a hot topic in biomedicine. In r‐and …

Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine

S Kopp, L Slumstrup, TJ Corydon, J Sahana… - Scientific reports, 2016 - nature.com
Many cell types form three-dimensional aggregates (MCS; multicellular spheroids), when
they are cultured under microgravity. MCS often resemble the organ, from which the cells …

Spheroid formation of human thyroid cancer cells in an automated culturing system during the Shenzhou-8 Space mission

J Pietsch, X Ma, M Wehland, G Aleshcheva… - Biomaterials, 2013 - Elsevier
Human follicular thyroid cancer cells were cultured in Space to investigate the impact of
microgravity on 3D growth. For this purpose, we designed and constructed a cell container …