The role of the cytoskeleton in sensing changes in gravity by nonspecialized cells
A large body of evidence indicates that single cells in vitro respond to changes in gravity,
and that this response might play an important role for physiological changes at the …
and that this response might play an important role for physiological changes at the …
Growing tissues in real and simulated microgravity: new methods for tissue engineering
Tissue engineering in simulated (s-) and real microgravity (r-μ g) is currently a topic in Space
medicine contributing to biomedical sciences and their applications on Earth. The principal …
medicine contributing to biomedical sciences and their applications on Earth. The principal …
The impact of microgravity and hypergravity on endothelial cells
JAM Maier, F Cialdai, M Monici… - BioMed research …, 2015 - Wiley Online Library
The endothelial cells (ECs), which line the inner surface of vessels, play a fundamental role
in maintaining vascular integrity and tissue homeostasis, since they regulate local blood flow …
in maintaining vascular integrity and tissue homeostasis, since they regulate local blood flow …
Real microgravity influences the cytoskeleton and focal adhesions in human breast cancer cells
With the increasing number of spaceflights, it is crucial to understand the changes occurring
in human cells exposed to real microgravity (r-µ g) conditions. We tested the effect of r-µ g on …
in human cells exposed to real microgravity (r-µ g) conditions. We tested the effect of r-µ g on …
Alterations of the cytoskeleton in human cells in space proved by life-cell imaging
TJ Corydon, S Kopp, M Wehland, M Braun, A Schütte… - Scientific reports, 2016 - nature.com
Microgravity induces changes in the cytoskeleton. This might have an impact on cells and
organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity …
organs of humans in space. Unfortunately, studies of cytoskeletal changes in microgravity …
The challenging environment on board the International Space Station affects endothelial cell function by triggering oxidative stress through thioredoxin interacting …
S Versari, G Longinotti, L Barenghi… - The FASEB …, 2013 - Wiley Online Library
Exposure to microgravity generates alterations that are similar to those involved in age‐
related diseases, such as cardiovascular deconditioning, bone loss, muscle atrophy, and …
related diseases, such as cardiovascular deconditioning, bone loss, muscle atrophy, and …
Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space
This study focuses on the effects of short‐term [22 s, parabolic flight campaign (PFC)] and
long‐term (10 d, Shenzhou 8 space mission) real microgravity on changes in cytokine …
long‐term (10 d, Shenzhou 8 space mission) real microgravity on changes in cytokine …
The impact of simulated and real microgravity on bone cells and mesenchymal stem cells
C Ulbrich, M Wehland, J Pietsch… - BioMed research …, 2014 - Wiley Online Library
How microgravity affects the biology of human cells and the formation of 3D cell cultures in
real and simulated microgravity (r‐and s‐µg) is currently a hot topic in biomedicine. In r‐and …
real and simulated microgravity (r‐and s‐µg) is currently a hot topic in biomedicine. In r‐and …
Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine
S Kopp, L Slumstrup, TJ Corydon, J Sahana… - Scientific reports, 2016 - nature.com
Many cell types form three-dimensional aggregates (MCS; multicellular spheroids), when
they are cultured under microgravity. MCS often resemble the organ, from which the cells …
they are cultured under microgravity. MCS often resemble the organ, from which the cells …
Spheroid formation of human thyroid cancer cells in an automated culturing system during the Shenzhou-8 Space mission
Human follicular thyroid cancer cells were cultured in Space to investigate the impact of
microgravity on 3D growth. For this purpose, we designed and constructed a cell container …
microgravity on 3D growth. For this purpose, we designed and constructed a cell container …