Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Visible-to-NIR-light activated release: from small molecules to nanomaterials

R Weinstain, T Slanina, D Kand, P Klan - Chemical reviews, 2020 - ACS Publications
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Recent advances in noble metal complex based photodynamic therapy

Y Wu, S Li, Y Chen, W He, Z Guo - Chemical Science, 2022 - pubs.rsc.org
Photodynamic therapy (PDT) utilizes light-activated photosensitizers (PSs) to generate toxic
species for therapeutics. It has become an emerging solution for cancer treatment because …

Taking phototherapeutics from concept to clinical launch

BM Vickerman, EM Zywot, TK Tarrant… - Nature Reviews …, 2021 - nature.com
More than four decades have passed since the first example of a light-activated (caged)
compound was described. In the intervening years, a large number of light-responsive …

Near Infrared (NIR) absorbing dyes as promising photosensitizer for photo dynamic therapy

PCA Swamy, G Sivaraman, RN Priyanka… - Coordination Chemistry …, 2020 - Elsevier
Abstract Photo Dynamic Therapy (PDT) is regarded as an effective therapeutic approach for
cancer, which employs light and photosensitizing chemical substances. The successful …

Recent progress on molecularly near-infrared fluorescent probes for chemotherapy and phototherapy

C Yan, Y Zhang, Z Guo - Coordination Chemistry Reviews, 2021 - Elsevier
Recently, molecularly fluorophores for nanotheranostics, bridging in vivo imaging and
therapeutic capability within unimolecular system, has attracted increasing attention …

Bioorthogonal chemistry for prodrug activation in vivo

Q Fu, S Shen, P Sun, Z Gu, Y Bai, X Wang… - Chemical Society …, 2023 - pubs.rsc.org
Prodrugs have emerged as a major strategy for addressing clinical challenges by improving
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …

Potential of cyanine derived dyes in photodynamic therapy

N Lange, W Szlasa, J Saczko, A Chwiłkowska - Pharmaceutics, 2021 - mdpi.com
Photodynamic therapy (PDT) is a method of cancer treatment that leads to the disintegration
of cancer cells and has developed significantly in recent years. The clinically used …

Transition metal complexes as photosensitizers for integrated cancer theranostic applications

J Li, T Chen - Coordination Chemistry Reviews, 2020 - Elsevier
Light, oxygen and photosensitizers (PSs) are the three separate elements that have been
applied in combination in the phototherapy of cancers in the past decades. Currently …

Anti-photobleaching cyanine-based nanoparticles with simultaneous PET and ACQ effects for improved tumor photothermal therapy

E Feng, L Jiao, S Tang, M Chen, S Lv, D Liu… - Chemical Engineering …, 2022 - Elsevier
To design anti-photobleaching photothermal agents (PTAs) is of great significance for tumor
photothermal therapy (PTT). Heptamethine cyanine (Cy7) dyes as one of near-infrared (NIR) …