Alzheimer Disease (AD) is a neurodegenerative disease characterized by two
neuropathological hallmarks: extracellular deposition of amyloid plaques and intracellular …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

Evidence for an ever-expanding variety of molecular mediators of amyloid β-protein
neurotoxicity (membrane lipids, receptor proteins, channel proteins, second messengers …

This review of Alzheimer's disease assembles a variety of findings relevant to the
mechanism of the disease and ties them together using the current understanding of the …

Alzheimer's disease is the most common cause of dementia in elderly people. Research into
Alzheimer's disease therapy has been at least partly successful in terms of developing …

Radical-mediated transformations have emerged as powerful methods for the synthesis of
rare and unnatural branched, deoxygenated, and isomeric sugars. Here, we describe a …

Alzheimer's disease is the largest unmet medical need in neurology. Current drugs improve
symptoms, but do not have profound disease-modifying effects. However, in recent years …

Alzheimer's Disease (AD) is a neurodegenerative disorder related with the increase of age
and it is the main cause of dementia in the world. AD affects cognitive functions, such as …

Significant insights into the function of genes associated with Alzheimer disease and related
dementias have occurred through studying genetically modified animals. Although none of …

The distinct protein aggregates that are found in Alzheimer's, Parkinson's, Huntington's and
prion diseases seem to cause these disorders. Small intermediates—soluble oligomers—in …