Digital twins in pharmaceutical and biopharmaceutical manufacturing: a literature review

Y Chen, O Yang, C Sampat, P Bhalode… - Processes, 2020 - mdpi.com
The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …

[HTML][HTML] Process analytical technologies–advances in bioprocess integration and future perspectives

G Gerzon, Y Sheng, M Kirkitadze - Journal of pharmaceutical and …, 2022 - Elsevier
Abstract Process Analytical Technology (PAT) instruments include analyzers capable of
measuring physical and chemical process parameters and key attributes with the goal of …

Paper electrode-based flexible pressure sensor for point-of-care immunoassay with digital multimeter

Z Yu, Y Tang, G Cai, R Ren, D Tang - Analytical chemistry, 2018 - ACS Publications
A novel paper electrode-based flexible pressure sensor modified with multiwalled carbon
nanotubes was designed for point-of-care (POC) immunoassay of carcinoembryonic antigen …

Bioprocess control: current progress and future perspectives

AS Rathore, S Mishra, S Nikita, P Priyanka - Life, 2021 - mdpi.com
Typical bioprocess comprises of different unit operations wherein a near optimal
environment is required for cells to grow, divide, and synthesize the desired product …

Modern sensor tools and techniques for monitoring, controlling, and improving cell culture processes

SJ Reyes, Y Durocher, PL Pham, O Henry - Processes, 2022 - mdpi.com
The growing biopharmaceutical industry has reached a level of maturity that allows for the
monitoring of numerous key variables for both process characterization and outcome …

Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes

CL Gargalo, I Udugama, K Pontius… - Journal of Industrial …, 2020 - academic.oup.com
The biomanufacturing industry has now the opportunity to upgrade its production processes
to be in harmony with the latest industrial revolution. Technology creates capabilities that …

Blueprints for biosensors: design, limitations, and applications

AC Carpenter, IT Paulsen, TC Williams - Genes, 2018 - mdpi.com
Biosensors are enabling major advances in the field of analytics that are both facilitating and
being facilitated by advances in synthetic biology. The ability of biosensors to rapidly and …

[HTML][HTML] Automation and artificial intelligence in filamentous fungi-based bioprocesses: A review

S Wainaina, MJ Taherzadeh - Bioresource Technology, 2023 - Elsevier
By utilizing their powerful metabolic versatility, filamentous fungi can be utilized in
bioprocesses aimed at achieving circular economy. With the current digital transformation …

Process analytical technologies and data analytics for the manufacture of monoclonal antibodies

MK Maruthamuthu, SR Rudge, AM Ardekani… - Trends in …, 2020 - cell.com
Process analytical technology (PAT) for the manufacture of monoclonal antibodies (mAbs) is
defined by an integrated set of advanced and automated methods that analyze the …

Challenges in the development of soft sensors for bioprocesses: A critical review

V Brunner, M Siegl, D Geier, T Becker - Frontiers in bioengineering …, 2021 - frontiersin.org
Among the greatest challenges in soft sensor development for bioprocesses are variable
process lengths, multiple process phases, and erroneous model inputs due to sensor faults …