Most of the currently marketed drugs consist of heterocyclic scaffolds containing nitrogen
and or oxygen as heteroatoms in their structures. Several research groups have synthesized …

Thiazole and oxazole are compounds with a heterocyclic nucleus that have attracted the
attention of medicinal chemistry due to the great variety of biological activities that they …

Thalidomide and its analogs are immunomodulatory drugs that inhibit the production of
certain inflammatory mediators associated with cancer. In the present work, a new series of …

A series of N-pyridyl ureas bearing 1, 2, 4-(1a, 2a, and 3a) and 1, 3, 4-oxadiazole moiety
(1b, 2b, 3b) was prepared and characterized by HRMS, 1H and 13C NMR spectroscopy, as …

Our present work demonstrates the successful design and synthesis of a new class of
compounds based upon a multitargeted directed ligand design approach to discover new …

The world's health system is plagued by cancer and a worldwide effort is underway to find
new drugs to treat cancer. There has been a significant improvement in understanding the …

Diosgenin, a naturally occurring steroidal saponin, has been confirmed to possess potent
anticancer properties. In the current work, two series of novel diosgenin derivatives bearing …

Cancer is one of the most prominent causes of death worldwide and tubulin is a crucial
protein of cytoskeleton that maintains essential cellular functions including cell division as …

Telomere and telomerase play important roles in abnormal cell proliferation, metastasis,
stem cell maintenance, and immortalization in various cancers. Therefore, designing of …

In this work, some new 2-[(5-((2-acetamidophenoxy) methyl)-1, 3, 4-oxadiazol-2-yl) thio]
acetamide derivatives (4a-4l) were synthesized and studied for their anticancer activity …