The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …

The complement activation product C3a is often described as a proinflammatory mediator,
alongside its downstream cousin, C5a. However, emerging studies show that C3a has …

Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute phase reaction that
has been implicated in the pathogenesis of several postoperative complications. Recent …

Our understanding of the biology of the complement system has undergone a drastic
metamorphosis since its original discovery. This system, which was traditionally primarily …

The complement system plays an essential role in alerting the host of the presence of
potential pathogens, as well as in their clearing. In addition, activation of the complement …

The complement system is a part of the immune system and consists of multiple complement
components with biological functions such as defense against pathogens and …

The activation of the complement cascade, a cornerstone of the innate immune response,
produces a number of small (74–77 amino acid) fragments, originally termed …

Septic shock and its frequent precursor, severe sepsis, are the most common causes of
morbidity and mortality in intensive care units today. Remarkably, almost 90% of the cases …

Despite significant research on the role of inflammation and immunosurveillance in the
immunologic microenvironment of tumors, little attention has been given to the oncogenic …

The function of the C5a receptors, C5ar (encoded by C5ar) and C5l2 (encoded by Gpr77),
especially of C5l2, which was originally termed a'default receptor', remains a controversial …