Paradoxical role of lipocalin-2 in metabolic disorders and neurological complications

A Bhusal, MH Rahman, WH Lee, YC Bae, IK Lee… - Biochemical …, 2019 - Elsevier
Abstract Lipocalin-2 (LCN2), also known as 24p3 and neutrophil gelatinase-associated
lipocalin (NGAL), is a 25-kDa secreted protein implicated in various metabolic and …

Newly discovered adipokines: pathophysiological link between obesity and cardiometabolic disorders

JA Kim, KM Choi - Frontiers in physiology, 2020 - frontiersin.org
With the increasing prevalence of obesity, obesity-related problems such as cardiometabolic
disorders (CMD), are also rapidly increasing. To prevent and alleviate the progressive …

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

KE Kim, J Lee, HJ Shin, EA Jeong, HM Jang, YJ Ahn… - Hepatology, 2023 - journals.lww.com
Lipocalin‐2 activates hepatic stellate cells and promotes no... : Hepatology Lipocalin‐2
activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed …

Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism

Y Xu, Y Li, K Jadhav, X Pan, Y Zhu, S Hu, S Chen… - Nature …, 2021 - nature.com
Activating transcription factor (ATF) 3 is known to have an anti-inflammatory function, yet the
role of hepatic ATF3 in lipoprotein metabolism or atherosclerosis remains unknown. Here …

Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice

Q Escalante-Covarrubias, L Mendoza-Viveros… - Nature …, 2023 - nature.com
The circadian clock is an endogenous time-tracking system that anticipates daily
environmental changes. Misalignment of the clock can cause obesity, which is accompanied …

Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis

R Moreno Traspas, TS Teoh, PM Wong, M Maier… - Nature …, 2022 - nature.com
Cirrhosis is usually a late-onset and life-threatening disease characterized by fibrotic
scarring and inflammation that disrupts liver architecture and function. While it is typically the …

Hepatocytic lipocalin-2 controls HDL metabolism and atherosclerosis via Nedd4-1-SR-BI axis in mice

S Hu, Y Zhu, X Zhao, R Li, G Shao, D Gong, C Hu… - Developmental Cell, 2023 - cell.com
High-density lipoprotein (HDL) metabolism is regulated by complex interplay between the
scavenger receptor group B type 1 (SR-BI) and multiple signaling molecules in the liver …

Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice

Y Xu, X Pan, S Hu, Y Zhu… - American Journal …, 2021 - journals.physiology.org
Human carboxylesterase 2 (CES2) has triacylglycerol hydrolase (TGH) activities and plays
an important role in lipolysis. In this study, we aim to determine the role of human CES2 in …

Inflammatory liver diseases and susceptibility to sepsis

H Lu - Clinical Science, 2024 - portlandpress.com
Patients with inflammatory liver diseases, particularly alcohol-associated liver disease and
metabolic dysfunction-associated fatty liver disease (MAFLD), have higher incidence of …

Atf3-mediated metabolic reprogramming in hepatic macrophage orchestrates metabolic dysfunction–associated steatohepatitis

S Hu, R Li, D Gong, P Hu, J Xu, Y Ai, X Zhao, C Hu… - Science …, 2024 - science.org
Metabolic dysfunction–associated steatohepatitis (MASH) is regulated by complex interplay
between the macrophages and surrounding cells in the liver. Here, we show that Atf3 …