Paradoxical role of lipocalin-2 in metabolic disorders and neurological complications
Abstract Lipocalin-2 (LCN2), also known as 24p3 and neutrophil gelatinase-associated
lipocalin (NGAL), is a 25-kDa secreted protein implicated in various metabolic and …
lipocalin (NGAL), is a 25-kDa secreted protein implicated in various metabolic and …
Newly discovered adipokines: pathophysiological link between obesity and cardiometabolic disorders
JA Kim, KM Choi - Frontiers in physiology, 2020 - frontiersin.org
With the increasing prevalence of obesity, obesity-related problems such as cardiometabolic
disorders (CMD), are also rapidly increasing. To prevent and alleviate the progressive …
disorders (CMD), are also rapidly increasing. To prevent and alleviate the progressive …
Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice
KE Kim, J Lee, HJ Shin, EA Jeong, HM Jang, YJ Ahn… - Hepatology, 2023 - journals.lww.com
Lipocalin‐2 activates hepatic stellate cells and promotes no... : Hepatology Lipocalin‐2
activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed …
activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed …
Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism
Activating transcription factor (ATF) 3 is known to have an anti-inflammatory function, yet the
role of hepatic ATF3 in lipoprotein metabolism or atherosclerosis remains unknown. Here …
role of hepatic ATF3 in lipoprotein metabolism or atherosclerosis remains unknown. Here …
Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice
Q Escalante-Covarrubias, L Mendoza-Viveros… - Nature …, 2023 - nature.com
The circadian clock is an endogenous time-tracking system that anticipates daily
environmental changes. Misalignment of the clock can cause obesity, which is accompanied …
environmental changes. Misalignment of the clock can cause obesity, which is accompanied …
Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis
R Moreno Traspas, TS Teoh, PM Wong, M Maier… - Nature …, 2022 - nature.com
Cirrhosis is usually a late-onset and life-threatening disease characterized by fibrotic
scarring and inflammation that disrupts liver architecture and function. While it is typically the …
scarring and inflammation that disrupts liver architecture and function. While it is typically the …
Hepatocytic lipocalin-2 controls HDL metabolism and atherosclerosis via Nedd4-1-SR-BI axis in mice
High-density lipoprotein (HDL) metabolism is regulated by complex interplay between the
scavenger receptor group B type 1 (SR-BI) and multiple signaling molecules in the liver …
scavenger receptor group B type 1 (SR-BI) and multiple signaling molecules in the liver …
Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice
Human carboxylesterase 2 (CES2) has triacylglycerol hydrolase (TGH) activities and plays
an important role in lipolysis. In this study, we aim to determine the role of human CES2 in …
an important role in lipolysis. In this study, we aim to determine the role of human CES2 in …
Inflammatory liver diseases and susceptibility to sepsis
H Lu - Clinical Science, 2024 - portlandpress.com
Patients with inflammatory liver diseases, particularly alcohol-associated liver disease and
metabolic dysfunction-associated fatty liver disease (MAFLD), have higher incidence of …
metabolic dysfunction-associated fatty liver disease (MAFLD), have higher incidence of …
Atf3-mediated metabolic reprogramming in hepatic macrophage orchestrates metabolic dysfunction–associated steatohepatitis
Metabolic dysfunction–associated steatohepatitis (MASH) is regulated by complex interplay
between the macrophages and surrounding cells in the liver. Here, we show that Atf3 …
between the macrophages and surrounding cells in the liver. Here, we show that Atf3 …