Insulin is a paramount anabolic hormone that promotes energy-storage in adipose tissue,
skeletal muscle and liver, and these responses are significantly attenuated in insulin …

White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels
in response to nutritional cues. WAT expands to store excess energy by increasing …

Autophagy plays a key role in cellular, tissue and organismal homeostasis and in the
production of the energy load needed at critical times during development and in response …

Type II diabetes mellitus (T2DM) is a chronic metabolic disease characterized by prolonged
hyperglycemia and insulin resistance (IR). Its incidence is increasing annually, posing a …

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose
levels and has become the third leading threat to human health after cancer and …

Background Electroacupuncture (EA), a treatment derived from traditional Chinese
medicine, can effectively improve hyperandrogenism and insulin resistance in patients with …

Type 2 diabetes mellitus (T2DM) is a major chronic disease that is characterized by
pancreatic β-cell dysfunction and insulin resistance. Autophagy is a highly conserved …

Irregularities in insulin signaling have significantly increased the risk of various cancers, yet
the precise underlying mechanisms remain unclear. Within our study, we observed that …

Hepatic insulin resistance is a hallmark feature of nonalcoholic fatty liver disease and type-2
diabetes and significantly contributes to systemic insulin resistance. Abnormal activation of …

Mitophagy is critical for mitochondrial quality control and function to clear damaged
mitochondria. Here, we found that Burkholderia pseudomallei maneuvered host mitophagy …