The platelet integrin α IIb β 3 undergoes long-range conformational transitions associated
with its functional conversion from inactive (low-affinity) to active (high-affinity) during …

Osmolytes are well known to protect the protein structure against different chemical and
physical denaturants. Since their actions with protein surfaces are mechanistically …

Polypeptide chains experience mechanical tension while translocating through cellular
tunnels, which are subsequently folded by molecular chaperones. However, interactions …

Single-molecule covalent magnetic tweezers Single-molecule covalent magnetic tweezers
Trends Biochem Sci. 2023 Aug;48(8):740-741. doi: 10.1016/j.tibs.2023.05.002. Epub 2023 …

We studied single F 3+ color centers in a LiF crystal with use of confocal fluorescence
microscopy method and time-correlated single photon counting technique; the dependences …

Hypertrophic cardiomyopathy (HCM) is a monogenic cardiovascular disorder that has been
poorly studied at the molecular, genetic, and computational levels. Here, we examined the …

In Gram-negative bacteria, periplasmic chaperones mediate the transport and folding of
outer membrane proteins. While their substrate interaction mechanisms are well studied …

Protein quality control in the endoplasmic reticulum (ER) maintains cellular proteostasis by
regulating protein folding, assembly, and degradation. While protein translocation from the …

The intricate nature of antigen-antibody interactions plays a pivotal role in immunological
responses. Despite the multitude of ligand-binding sites on antigens, the influence of …

Methotrexate is a well-known antineoplastic drug used to prevent cancer aggravation.
Despite being a targeted therapeutic approach, its administration comes with the risk of …