In order to optimize a lead molecule for further development, bioisosteric replacements are
generally adopted as one of the strategies. Silicon appears to be the right choice as a …

Bioisosterism is one of the leading strategies in medicinal chemistry for the design and
modification of drugs, consisting in replacing an atom or a substituent with a different atom or …

Nucleoside and nucleobase antimetabolites have substantially impacted treatment of cancer
and infections. Their close resemblance to natural analogs gives them the power to interfere …

The effects of standard adenosine receptor (AR) agonists and antagonists on the
proliferation of human T lymphocytes, unstimulated and phytohemagglutinin-stimulated …

This review aims to highlight the role of silicon in drug discovery. Silicon and carbon are
often regarded as being similar with silicon located directly beneath carbon in the same …

Seventeen silyl-and trityl-modified (5′-O-and 3′, 5′-di-O-) nucleosides were synthesized
with the aim of investigating the in vitro antiproliferative activities of these nucleoside …

A series of 2′, 3′-bis-O-silylated or-acylated derivatives of lead compound 3a (2′, 3′-
bis-O-tert-butyldimethylsilyl-5′-deoxy-5′-(N-methylcarbamoyl) amino-N6-(N …

A series of 5-substituted 3-phosphonylated isoxazolidines have been obtained via
cycloaddition of N-methyl-C-(diethoxyphosphoryl) nitrone with N-heteroaromatic …

Arylurea derivatives, an important class of small molecules, have received considerable
attention in recent years due to their wide range of biological applications. Various …

Synthesis of orthogonally protected 2‐silyl nucleosides were achieved by trans opening of
sugar epoxides with nucleobases catalyzed by trimethylsilyltrifluoromethanesulfonate using …