Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

Arynes, strained cyclic alkynes, and strained cyclic allenes were validated as plausible
intermediates in the 1950s and 1960s. Despite initially being considered mere scientific …

With the advent of bioconjugation chemistry in the last two decades, highlighted by the
Nobel Prize 2022, the quest for possible novel applications has been greatly intensified …

In the search for fundamentally new, active, stable, and readily synthetically accessible
cycloalkynes as strain-promoted azide–alkyne cycloaddition (SPAAC) reagents for …

A rhodium-catalyzed [7+ 1] reaction of exocyclic 1, 3-dienylcyclopropanes and carbon
monoxide has been developed to synthesize eight-membered carbocycle-embedded …

The chemistry of strained cyclic alkynes has undergone a renaissance over the past two
decades. However, a related species, strained cyclic allenes, especially heterocyclic …

The reaction of 4, 4-dichloro-1, 2-diazabuta-1, 3-dienes with sodium azide has been studied
and found to provide straightforward access to extremely rare 1, 1-bisazides. It was …

Organic azides are still in the center of click chemistry connecting two molecules. However,
taming the conjugation selectivity of azides is difficult without the help of bulky groups. We …

This paper reports on the selective conversion of alkyl azido groups at the carbonyl α-
position to diazo compounds. Through β-elimination of dinitrogen, followed by hydrazone …

Going beyond the conventional approach of pairwise conjugation between two molecules,
the integration of multiple components onto a central scaffold molecule is essential for the …