Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …

During the processes leading to adverse cardiac remodeling and heart failure,
cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating …

Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its
underlying mechanisms remain elusive. Here we reconstruct a trajectory of cardiomyocyte …

Calcium signaling is a central regulator of cardiomyocyte growth and function. Calmodulin is
a critical mediator of calcium signals. Because the amount of calmodulin within …

Rationale: An increase in cardiac afterload typically produces concentric hypertrophy
characterized by an increase in cardiomyocyte width, whereas volume overload or exercise …

Background—Dicer, an RNAse III endonuclease critical for processing of pre-microRNAs
(miRNAs) into mature 22-nucleotide miRNAs, has proven a useful target to dissect the …

Background: Hypertensive ventricular remodeling is a common cause of heart failure.
However, the molecular mechanisms regulating ventricular remodeling remain poorly …

The adult heart responds to excessive neurohumoral signaling and workload by a
pathological growth response characterized by hypertrophy of cardiomyocytes and …

Cardiac hypertrophy is a common response to injury and hemodynamic stress and an
important harbinger of heart failure and death. Herein, we identify the Kruppel-like factor 15 …

Although aberrant reactivation of embryonic gene programs is intricately linked to
pathological heart disease, the transcription factors driving these gene programs remain ill …