The role of the glutathione system in stress adaptation, morphogenesis and virulence of pathogenic fungi

T Wangsanut, M Pongpom - International Journal of Molecular Sciences, 2022 - mdpi.com
Morphogenesis and stress adaptation are key attributes that allow fungal pathogens to thrive
and infect human hosts. During infection, many fungal pathogens undergo morphological …

Updates in Paracoccidioides Biology and Genetic Advances in Fungus Manipulation

AFA Chaves, MV Navarro, YN de Barros, RS Silva… - Journal of Fungi, 2021 - mdpi.com
The dimorphic fungi of the Paracoccidioides genus are the causative agents of
paracoccidioidomycosis (PCM). This disease is endemic in Latin America and primarily …

Transcriptional profiling of a fungal granuloma reveals a low metabolic activity of Paracoccidioides brasiliensis yeasts and an actively regulated host immune …

BM Borges, RBC Ramos, NW Preite… - Frontiers in Cellular …, 2023 - frontiersin.org
Granulomas are important immunological structures in the host defense against the fungus
Paracoccidioides brasiliensis, the main etiologic agent of Paracoccidioidomycosis (PCM), a …

Extracellular Vesicles From Paracoccidioides brasiliensis Can Induce the Expression of Fungal Virulence Traits In Vitro and Enhance Infection in Mice

CE Octaviano, NE Abrantes, R Puccia - Frontiers in Cellular and …, 2022 - frontiersin.org
Extracellular vesicles (EVs) are cellular components involved in cargo delivery to the
extracellular environment, including the fungal cell wall. Their importance in cell–cell …

The Role of Dimorphism Regulating Histidine Kinase (Drk1) in the Pathogenic Fungus Paracoccidioides brasiliensis Cell Wall

MV Navarro, YN de Barros, WD Segura, AFA Chaves… - Journal of Fungi, 2021 - mdpi.com
Dimorphic fungi of the Paracoccidioides genus are the causative agents of
paracoccidioidomycosis (PCM), an endemic disease in Latin America with a high incidence …

The Human Pathogen Paracoccidioides brasiliensis Has a Unique 1-Cys Peroxiredoxin That Localizes Both Intracellularly and at the Cell Surface

LVG Longo, CA Breyer, GM Novaes… - Frontiers in Cellular …, 2020 - frontiersin.org
Paracoccidioides brasiliensis is a temperature-dependent dimorphic fungus that causes
systemic paracoccidioidomycosis, a granulomatous disease. The massive production of …

Characterization of Aspartic Proteases from Paracoccidioides brasiliensis and Their Role in Fungal Thermo-Dimorphism

RS Silva, WD Segura, RS Oliveira, P Xander… - Journal of Fungi, 2023 - mdpi.com
Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America and
is caused by fungi from the Paracoccidioides genus. The infection begins after inhalation of …

Dectin-2 is critical for phagocyte function and resistance to Paracoccidioides brasiliensis in mice

MRD Cardoso-Miguel, PH Bürgel… - Medical …, 2023 - academic.oup.com
Germline-encoded pattern recognition receptors, particularly C-type lectin receptors (CLRs),
are essential for phagocytes to sense invading fungal cells. Among CLRs, Dectin-2 …

Effect of Nitrosative Stress on the S-Nitroso-Proteome of Paracoccidioides brasiliensis

MV Navarro, AFA Chaves, DG Castilho… - Frontiers in …, 2020 - frontiersin.org
The fungi Paracoccidioides brasiliensis and Paracoccidioides lutzii are the causative agents
of paracoccidioidomycosis (PCM), a systemic mycosis endemic to Latin America. This …

Exposure of Paracoccidioides brasiliensis to Mebendazole Leads to Inhibition of Fungal Energy Production

OB Rocha, KSF e Silva, D Moraes, CL Borges… - Antibiotics, 2023 - mdpi.com
Paracoccidioidomycosis (PCM) is a fungal disease caused by organisms of the genus
Paracoccidioides spp. The treatment of the disease is lengthy and includes several adverse …