Viral infections have a major impact in human health. Ongoing viral transmission and
escalating selective pressure have the potential to favor the emergence of vaccine-and …

Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction
of the innate immune response to influenza virus infection results in hypercytokinemia …

In the current study, two series of novel thiazolidin-4-one benzenesulfonamide arylidene
hybrids 9a-l and 10a-f were designed, synthesized and tested in vitro for their PPARɣ …

The balance between active oxidizing species and active reducing species plays an
important role in cell metabolism. A multitude of excellent probes can be used for the …

To address drug resistance to influenza virus neuraminidase inhibitors (NAIs), a series of
novel boron-containing N-substituted oseltamivir derivatives were designed and …

In the current work, a series of novel 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate
hybrids (10a-o) and (11a-e) were synthesized and evaluated as new PPARα agonists in …

Abstract Development and design of anti-influenza drugs with novel mechanisms is of great
significance to combat the ongoing threat of influenza A virus (IAV). Hemagglutinin (HA) is …

To yield potent neuraminidase inhibitors with improved drug resistance and favorable drug-
like properties, two series of novel oseltamivir derivatives targeting the 150-cavity of …

Although vaccination remains the prevalent prophylactic means for controlling Influenza A
virus (IAV) infections, novel structural antivirus small-molecule drugs with new mechanisms …

Inspired by our previous finding that targeting the 150-cavity with a multisite-binding strategy
emerged as an effective approach to obtain more potent and selective neuraminidase (NA) …