The number of microbiome-related studies has notably increased the availability of data on
human microbiome composition and function. These studies provide the essential material …

Increasingly, researchers are discovering associations between microbiome and a wide
range of human diseases such as obesity, inflammatory bowel diseases, HIV, and so on …

Motivation Estimating microbial association networks from high-throughput sequencing data
is a common exploratory data analysis approach aiming at understanding the complex …

Differential abundance analysis is controversial throughout microbiome research. Gold
standard approaches require laborious measurements of total microbial load, or absolute …

Marker-gene and metagenomic sequencing have profoundly expanded our ability to
measure biological communities. But the measurements they provide differ from the truth …

Multiple clinical trials targeting the gut microbiome are being conducted to optimize
treatment outcomes for immune checkpoint blockade (ICB). To improve the success of these …

The central aims of many host or environmental microbiome studies are to elucidate factors
associated with microbial community compositions and to relate microbial features to …

Background Next-generation sequencing (NGS) has made it possible to determine the
sequence and relative abundance of all nucleotides in a biological or environmental …

Understanding the role of the microbiome in human health and how it can be modulated is
becoming increasingly relevant for preventive medicine and for the medical management of …

Many tools for dealing with compositional ''omics' data produce feature-wise values that can
be ranked in order to describe features' associations with some sort of variation. These …