Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as
promising candidate targets for cancer treatment. These proteins complexed with cyclins …

Runx2 is a master transcription factor for osteogenesis. The most important phenomenon
that makes this protein a master regulator for osteogenesis is its structural integrity. In …

Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related transcription factor
that has emerged as a prominent transcription repressing factor in carcinogenesis. However …

The Runt‐related transcription factors (RUNX) belong to an ancient family of metazoan
genes involved in developmental processes. Through multiple protein‐interacting partners …

The Runx2 transcription factor is required for commitment of mesenchymal cells to bone
lineages and is a major regulator of osteoblast-specific gene expression. Runx2 is subject to …

Background: Chronic kidney disease (CKD) accelerates vascular calcification via
phenotypic switching of vascular smooth muscle cells (VSMCs). We investigated the roles of …

A characteristic sign of zinc deficiency is retarded skeletal growth, but the role of zinc in
osteoblasts is not well understood. Two major events for bone formation include osteoblast …

The three mammalian Runt homology domain transcription factors (Runx1, Runx2, Runx3)
support biological control by functioning as master regulatory genes for the differentiation of …