T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible
for most cases of viral hepatitis. Infection by each type of virus results in a different typical …

Hepatocellular carcinoma (HCC) is one of most common cancers and the fourth leading
cause of death worldwide. Commonly, HCC development occurs in a liver that is severely …

The successes of antitumor immuno-based therapies and the application of next-generation
sequencing to mutation profiling have produced insights into the specific targets of antitumor …

Tissue resident memory T cells (TRM) have been identified in various tissues, however
human liver TRM to date remain unidentified. TRM can be recognized by CD69 and/or …

Hepatitis C virus (HCV) remains a global public health problem even though more than 95%
of infections can be cured by treatment with direct-acting antiviral agents. Resolution of …

Abstract Background Although DAAs hold promise to significantly reduce rates of chronic
HCV infections, its eradication still requires development of an effective vaccine. Prolonged …

Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural
killer cells, where they play a key role in the regulation of innate immune responses. Recent …

Background Hepatocellular carcinoma is a pathological type of liver cancer and accounts for
the majority of primary liver cancers. We conducted a meta-analysis to evaluate the efficacy …

Altered immune parameters associated with hepatitis C virus (HCV) genotype 1b infection
and their correlation with virus eradication in direct‐acting antivirals (DAA)‐treated patients …