Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung
injury can affect several components of the respiratory system, including the airways …

Mechanical ventilation with hyperoxia is necessary to treat critically ill patients. However,
prolonged exposure to hyperoxia leads to the generation of excessive reactive oxygen …

A unique feature of human alveolar macrophages is their prolonged survival in the face of a
stressful environment. We have shown previously that the ERK MAPK is constitutively active …

In this study, we investigated the regulation and mechanism of IL-8 expression by A549
human lung carcinoma cells treated with neutrophil elastase (NE). NE-treated cells exhibited …

Oxygen toxicity is one of the major risk factors in the development of the chronic lung
disease or bronchopulmonary dysplasia in premature infants. Using proteomic analysis, we …

Exposure to supraphysiological concentrations of oxygen is often applied in clinical practice
to enhance oxygenation in acute or chronic lung injury. However, hyperoxic exposure is …

Oxidative injury to the lung is associated with widespread injury to the alveolar epithelium,
which can be fatal unless the process is controlled and repaired. Keratinocyte growth factor …

Aims. Studies have linked severe hyperoxia, or prolonged exposure to very high oxygen
levels, with worse clinical outcomes. This study investigated the role of epidermal growth …

High oxygen concentrations (hyperoxia), often required in the treatment of preterm infants
and critically ill patients, cause lung injury, targeting especially the endothelium. Exposure of …

We have used gene expression profiling approaches to identify new molecular targets in
various models of lung injury and human lung diseases. Among the many genes that are …