Background The introduction of proton pump inhibitors (PPIs) into clinical practice has
revolutionized the management of acid-related diseases. Studies in primary care and …

Background Proton pump inhibitors (PPIs) are a class of medications that reduce acid
secretion and are used for treating many conditions such as gastroesophageal reflux …

Gastro-oesophageal reflux disease refers to reflux of gastric contents into the oesophagus
leading to oesophagitis, reflux symptoms sufficient to impair quality of life, or long-term …

Gastric acid secretion is a complex phenomenon under nervous and hormonal influence.
The stimulation of proton pump (H+, K+-ATPase) in the parietal cell represents the final step …

Abstract Background and Aims: Since the publication of the Asia‐Pacific GERD consensus
in 2004, more data concerning the epidemiology and management of gastroesophageal …

Background Vitamin B 12 (cobalamin) deficiency can result in irreversible structural brain
changes if not treated appropriately. Long‐term use of acid‐lowering agents (ALA) has been …

Acid peptic disorders are the result of distinctive, but overlapping pathogenic mechanisms
leading to either excessive acid secretion or diminished mucosal defense. They are …

Background Proton pump inhibitors (PPI) therapy 'on‐demand'is often used as an alternative
to continuous maintenance therapy in gastro‐oesophageal reflux disease (GERD). Aim We …

The dramatic success of pharmacological acid suppression in healing peptic ulcers and
managing patients with gastroesophageal reflux disease (GERD) has been reflected in the …

Alcohol dehydrogenases (ADHs) are most known for their roles in oxidation and elimination
of ethanol. Although less known, ADHs also play a critical role in the metabolism of a …