Complete and accurate DNA replication requires the progression of replication forks through
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …

Damage to our genetic material is an ongoing threat to both our ability to faithfully transmit
genetic information to our offspring as well as our own survival. To respond to these threats …

The primary causes of chronic kidney disease (CKD) in children differ from those of CKD in
adults. In the USA the most common diagnostic groups of renal disease that manifest before …

Results In 74 of 300 families (25%), we identified a causative mutation in one of 20 genes
known to cause steroid-resistant nephrotic syndrome. In 11 families (3.7%), we detected a …

The DNA damage response kinase ataxia telangiectasia and Rad3-related (ATR)
coordinates much of the cellular response to replication stress. The exact mechanisms by …

Childhood nephrotic syndromes are most commonly caused by one of two idiopathic
diseases: minimal-change nephrotic syndrome (MCNS) and focal segmental …

In the last years, advances in molecular genetics and immunology have resulted in the
identification of a growing number of genes causing primary immunodeficiencies (PIDs) in …

Endometrial cancer is the sixth most commonly diagnosed cancer in women worldwide,
causing∼ 74,000 deaths annually. Serous endometrial cancers are a clinically aggressive …

The Snf2 family of helicase-related proteins includes the catalytic subunits of ATP-
dependent chromatin remodelling complexes found in all eukaryotes. These act to regulate …

DNA replication is a fundamental process of the cell that ensures accurate duplication of the
genetic information and subsequent transfer to daughter cells. Various pertubations …