Zinc complexes with nitrogen donor ligands as anticancer agents

M Porchia, M Pellei, F Del Bello, C Santini - Molecules, 2020 - mdpi.com
The search for anticancer metal-based drugs alternative to platinum derivatives could not
exclude zinc derivatives due to the importance of this metal for the correct functioning of the …

1, 3, 5-Triazines: A promising scaffold for anticancer drugs development

S Cascioferro, B Parrino, V Spanò, A Carbone… - European journal of …, 2017 - Elsevier
This review covering literature reports from the beginning of this century to 2016 describes
the synthetic pathways, the antitumor activity, the structure-activity relationship and …

Copper complexes as artificial DNA metallonucleases: from Sigman's reagent to next generation anti-cancer agent?

TJP McGivern, S Afsharpour, CJ Marmion - Inorganica Chimica Acta, 2018 - Elsevier
Platinum drugs continue to dominate medical oncology treatments but they have
shortcomings associated with their use including dose-limiting toxic side effects and …

Copper complexes as antitumor agents: In vitro and in vivo evidence

LM Balsa, EJ Baran, IE León - Current medicinal chemistry, 2023 - ingentaconnect.com
Copper is an essential element for most aerobic organisms, with an important function as a
structural and catalytic cofactor, and in consequence, it is implicated in several biological …

Endogenous generation of singlet oxygen and ozone in human and animal tissues: mechanisms, biological significance, and influence of dietary components

AN Onyango - Oxidative Medicine and Cellular Longevity, 2016 - Wiley Online Library
Recent studies have shown that exposing antibodies or amino acids to singlet oxygen
results in the formation of ozone (or an ozone‐like oxidant) and hydrogen peroxide and that …

Transition-metal norharmane compounds as possible cytotoxic agents: New insights based on a coordination chemistry perspective

RA Khan, A De Almeida, K Al-Farhan, A Alsalme… - Journal of Inorganic …, 2016 - Elsevier
New first-row transition-metal compounds with the ligand norharmane (9H-Pyrido [3, 4-b]
indole; Hnor) are reported. The compounds have the general formula [M (LL)(Hnor)(NO 3) …

Three structurally related Copper complexes with two isomers: DNA/BSA binding ability, DNA cleavage activity and excellent cytotoxicity

DY Zhang, Y Nie, H Sang, JJ Suo, ZJ Li, W Gu… - Inorganica Chimica …, 2017 - Elsevier
Three Cu (II) complexes of [Cu (L 1)(Br) 2]· CH 3 CN (1),[Cu (L 2) 2 (OAc)](PF 6)· 2C 2 H 5
OH (2), and [Cu (L 1)(L 2)](PF 6) 2 (3)(L 1= 2-(6-(pyridine-2-yl)-4-p-tolylpyridin-2-yl) pyridine …

A vanillin-based copper (II) metal complex with a DNA-mediated apoptotic activity

WMTQ de Medeiros, MJC de Medeiros, EM Carvalho… - RSC …, 2018 - pubs.rsc.org
Vanillin (vanH) is the major component of vanilla and one of the most widely used flavoring
agents. In this work the complex [Cu (phen)(van) 2] was prepared and characterized by …

Synthesis, DNA/HSA interaction spectroscopic studies and in vitro cytotoxicity of a new mixed ligand Cu (II) complex

Q Gan, X Fu, W Chen, Y Xiong, Y Fu, S Chen… - Journal of …, 2016 - Springer
A new mixed ligand copper (II)-dipeptide complex with 2-(2′-pyridyl) benzothiazole
(pbt),[Cu (Gly-L-leu)(pbt)(H 2 O)]· ClO 4 (Gly-L-leu= Glycyl-L-leucine anion) was synthesized …

Weakly antiferromagnetic vanillin and acetate bridged dinuclear Ni (ii) compound exhibiting catecholase-like activity and biological properties

BK Vernekar, NN Harmalkar, SK Gaonkar… - New Journal of …, 2024 - pubs.rsc.org
A dinuclear nickel compound that features vanillin (van) and acetate (OAc) bridging
ligands,[Ni2 (μ-van) 2 (μ-OAc)(NCS) 3 (H2O)]· 5H2O 1, was synthesized and characterized …