2, 5-Diketopiperazines: synthesis, reactions, medicinal chemistry, and bioactive natural products
AD Borthwick - Chemical reviews, 2012 - ACS Publications
2, 5-Diketopiperazines (2, 5-DKPs) are cyclodipeptides obtained by the condensation of two
α-amino acids. They not only abound in nature but are often produced as degradation …
α-amino acids. They not only abound in nature but are often produced as degradation …
3-Substituted-3-hydroxy-2-oxindole, an emerging new scaffold for drug discovery with potential anti-cancer and other biological activities
S Peddibhotla - Current Bioactive Compounds, 2009 - ingentaconnect.com
Natural products and small molecules inspired by them are enjoying a resurgence of interest
because they intersect biological space effectively and selectively. On account of their …
because they intersect biological space effectively and selectively. On account of their …
Recent Advances in Palladium‐Catalyzed Cascade Cyclizations
The importance of palladium‐catalyzed cross coupling reactions in contemporary organic
synthesis is undisputed and underlined by the Nobel Prize for Chemistry in 2010. In addition …
synthesis is undisputed and underlined by the Nobel Prize for Chemistry in 2010. In addition …
Enantioselective organocatalytic aldol reaction using small organic molecules
Enantioselective reactions catalyzed by small organic molecules (asymmetric
organocatalysis) have emerged as one of the most elegant cutting-edge strategies of …
organocatalysis) have emerged as one of the most elegant cutting-edge strategies of …
Lewis acid-catalyzed enantioselective hydroxylation reactions of oxindoles and β-keto esters using DBFOX ligand
T Ishimaru, N Shibata, J Nagai… - Journal of the …, 2006 - ACS Publications
The first catalytic enantioselective hydroxylation reaction of both 3-aryl and 3-alkyl-2-
oxindoles using the DBFOX− Zn (II) complex, leading to pharmaceutically important chiral 3 …
oxindoles using the DBFOX− Zn (II) complex, leading to pharmaceutically important chiral 3 …
Catalytic asymmetric hydroxylation of oxindoles by molecular oxygen using a phase-transfer catalyst
D Sano, K Nagata, T Itoh - Organic Letters, 2008 - ACS Publications
The highly enantioselective catalytic hydroxylation of 3-substituted oxindoles was achieved
by using a phase-transfer catalyst with molecular oxygen as an oxidant. The product then …
by using a phase-transfer catalyst with molecular oxygen as an oxidant. The product then …
Catalytic asymmetric synthesis of 3-hydroxyoxindole: a potentially bioactive molecule
The recent emergence of biological activities of chiral 3-substituted-3-hydroxy-2-oxindoles
has inspired synthetic chemists to develop new methodologies for their synthesis. Both …
has inspired synthetic chemists to develop new methodologies for their synthesis. Both …
Organocatalytic asymmetric aldol reaction of ketones with isatins: straightforward stereoselective synthesis of 3-alkyl-3-hydroxyindolin-2-ones
JR Chen, XP Liu, XY Zhu, L Li, YF Qiao, JM Zhang… - Tetrahedron, 2007 - Elsevier
An efficient asymmetric aldol condensation of ketones with isatins has been developed
using an l-proline-derived bifunctional organocatalyst. This strategy allows the …
using an l-proline-derived bifunctional organocatalyst. This strategy allows the …
Facile and One-Pot Access of 3,3-Bis(indol-3-yl)indolin-2-ones and 2,2-Bis(indol-3-yl)acenaphthylen-1(2H)-one Derivatives via an Eco-Friendly Pseudo …
G Brahmachari, B Banerjee - ACS Sustainable Chemistry & …, 2014 - ACS Publications
A simple, straightforward, and highly efficient pseudo-three-component one-pot synthesis of
a series of pharmaceutically interesting functionalized 3, 3-bis (indol-3-yl) indolin-2-ones (3a …
a series of pharmaceutically interesting functionalized 3, 3-bis (indol-3-yl) indolin-2-ones (3a …
Metal-free iodine-catalyzed synthesis of fully substituted pyrazoles and its sulphenylation
J Sun, JK Qiu, YL Zhu, C Guo, WJ Hao… - The Journal of …, 2015 - ACS Publications
A direct and metal-free access toward fully substituted pyrazoles and its sulphenylation has
been established through an iodine-mediated three-component [3+ 2] annulation of β …
been established through an iodine-mediated three-component [3+ 2] annulation of β …