Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies
Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …
ARF family G proteins and their regulators: roles in membrane transport, development and disease
JG Donaldson, CL Jackson - Nature reviews Molecular cell biology, 2011 - nature.com
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide-binding (G)
proteins, including the ARF-like (ARL) proteins and SAR1, regulate membrane traffic and …
proteins, including the ARF-like (ARL) proteins and SAR1, regulate membrane traffic and …
Protein lipidation in cell signaling and diseases: function, regulation, and therapeutic opportunities
B Chen, Y Sun, J Niu, GK Jarugumilli, X Wu - Cell chemical biology, 2018 - cell.com
Protein lipidation is an important co-or posttranslational modification in which lipid moieties
are covalently attached to proteins. Lipidation markedly increases the hydrophobicity of …
are covalently attached to proteins. Lipidation markedly increases the hydrophobicity of …
Fatty acylation of proteins: The long and the short of it
MD Resh - Progress in lipid research, 2016 - Elsevier
Long, short and medium chain fatty acids are covalently attached to hundreds of proteins.
Each fatty acid confers distinct biochemical properties, enabling fatty acylation to regulate …
Each fatty acid confers distinct biochemical properties, enabling fatty acylation to regulate …
An overview on target-based drug design against kinetoplastid protozoan infections: Human African trypanosomiasis, Chagas disease and leishmaniases
V Kourbeli, E Chontzopoulou, K Moschovou, D Pavlos… - Molecules, 2021 - mdpi.com
The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and
leishmaniases span worldwide and therefore their impact is a universal concern. The …
leishmaniases span worldwide and therefore their impact is a universal concern. The …
Recent advances in drug delivery and targeting to the brain
Our body keeps separating the toxic chemicals in the blood from the brain. A significant
number of drugs do not enter the central nervous system (CNS) due to the blood-brain …
number of drugs do not enter the central nervous system (CNS) due to the blood-brain …
Natively Inhibited Trypanosoma brucei Cathepsin B Structure Determined by Using an X-ray Laser
The Trypanosoma brucei cysteine protease cathepsin B (TbCatB), which is involved in host
protein degradation, is a promising target to develop new treatments against sleeping …
protein degradation, is a promising target to develop new treatments against sleeping …
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells
Protein N-myristoylation is a ubiquitous co-and post-translational modification that has been
implicated in the development and progression of a range of human diseases. Here, we …
implicated in the development and progression of a range of human diseases. Here, we …
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis
RT Jacobs, B Nare, SA Wring, MD Orr… - PLoS neglected …, 2011 - journals.plos.org
Background Human African trypanosomiasis (HAT) is an important public health problem in
sub-Saharan Africa, affecting hundreds of thousands of individuals. An urgent need exists …
sub-Saharan Africa, affecting hundreds of thousands of individuals. An urgent need exists …