TRP channel proteins constitute a large and diverse family of proteins that are expressed in
many tissues and cell types. This family was designated TRP because of a spontaneously …

The original idea that calcium might enter cells through a capacitative mechanism was first
introduced by Jim Putney [1]. The somewhat surprising hypothesis was that calcium entry …

In many vertebrate and invertebrate cells, inositol 1, 4, 5-trisphospate production induces a
biphasic Ca2+ signal. Mobilization of Ca2+ from internal stores drives the initial burst. The …

Although cyclic nucleotide-gated channels mediate sensory transduction in olfaction and
vision, other forms of sensory transduction are independent of these channels …

Mammalian transient receptor potential channels (TRPCs) form a family of Ca 2+-permeable
cation channels currently consisting of seven members, TRPC1–TRPC7. These channels …

Drosophila phototransduction is a G protein–coupled, calcium-regulated signaling cascade
that serves as a model system for the dissection of phospholipase C (PLC) signaling in vivo …

Hormonal stimulation of G q-protein coupled receptors triggers Ca 2+ mobilization from
internal stores. This is followed by a Ca 2+ entry through the plasma membrane. Drosophila …

▪ Abstract The Drosophila phototransduction cascade has emerged as an attractive
paradigm for understanding the molecular mechanisms underlying visual transduction, as …

We can now measure the connectivity of every neuron in a neural circuit, but we are still
blind to other biological details, including the dynamical characteristics of each neuron. The …

In Drosophila, the store-operated Ca 2+ channel, TRP, is required in photoreceptor cells for
a sustained response to light. Here, we show that TRP forms a complex with phospholipase …