Treatment of multiple sclerosis—success from bench to bedside

M Tintore, A Vidal-Jordana… - Nature Reviews …, 2019 - nature.com
The modern era of multiple sclerosis (MS) treatment began 25 years ago, with the approval
of IFNβ and glatiramer acetate for the treatment of relapsing–remitting MS. Ten years later …

Multiple sclerosis: current and emerging disease-modifying therapies and treatment strategies

DM Wingerchuk, JL Carter - Mayo Clinic Proceedings, 2014 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory demyelinating central nervous system
disease that typically strikes young adults, especially women. The pathobiology of MS …

ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis

X Montalban, R Gold, AJ Thompson… - Multiple Sclerosis …, 2018 - journals.sagepub.com
Background: Multiple sclerosis (MS) is a complex disease with new drugs becoming
available in the past years. There is a need for a reference tool compiling current data to aid …

Efficacy classification of modern therapies in multiple sclerosis

IA Samjoo, E Worthington, C Drudge… - Journal of …, 2021 - becarispublishing.com
Background: The Association of British Neurologists (ABN) 2015 guidelines suggested
classifying multiple sclerosis therapies according to their average relapse reduction. We …

Immunological aspects of approved MS therapeutics

PS Rommer, R Milo, MH Han, S Satyanarayan… - Frontiers in …, 2019 - frontiersin.org
Multiple sclerosis (MS) is the most common neurological immune-mediated disease leading
to disability in young adults. The outcome of the disease is unpredictable, and over time …

Disease-modifying therapies and infectious risks in multiple sclerosis

A Winkelmann, M Loebermann, EC Reisinger… - Nature Reviews …, 2016 - nature.com
Immunomodulatory and immunosuppressive treatments for multiple sclerosis (MS) are
associated with an increased risk of infection, which makes treatment of this condition …

Immunomodulators and immunosuppressants for relapsing‐remitting multiple sclerosis: a network meta‐analysis

I Tramacere, C Del Giovane, G Salanti… - Cochrane Database …, 2015 - cochranelibrary.com
Background Different therapeutic strategies are available for the treatment of people with
relapsing‐remitting multiple sclerosis (RRMS), including immunomodulators …

Current and emerging disease‐modulatory therapies and treatment targets for multiple sclerosis

F Piehl - Journal of Internal Medicine, 2021 - Wiley Online Library
The treatment of multiple sclerosis (MS), the most common chronic inflammatory,
demyelinating and neurodegenerative disease of the central nervous system (CNS) …

Brain atrophy in multiple sclerosis: mechanisms, clinical relevance and treatment options

A Andravizou, E Dardiotis, A Artemiadis… - Autoimmunity …, 2019 - Springer
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system
characterized by focal or diffuse inflammation, demyelination, axonal loss and …

Disease modifying therapies for relapsing multiple sclerosis

DM Wingerchuk, BG Weinshenker - Bmj, 2016 - bmj.com
Multiple sclerosis (MS) is a common, disabling, putatively autoimmune neurological disease
with worldwide distribution. It typically begins as a relapsing disorder that later evolves to a …