Biological factors underlying sex differences in neurological disorders
The prevalence, age of onset, pathophysiology, and symptomatology of many neurological
and neuropsychiatric conditions differ significantly between males and females. Females …
and neuropsychiatric conditions differ significantly between males and females. Females …
[HTML][HTML] Synaptic vesicle protein 2A as a potential biomarker in synaptopathies
Measuring synaptic density in vivo using positron emission tomography (PET) imaging-
based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much …
based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much …
Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease
Autologous transplantation of patient-specific induced pluripotent stem cell (iPSC)-derived
neurons is a potential clinical approach for treatment of neurological disease. Preclinical …
neurons is a potential clinical approach for treatment of neurological disease. Preclinical …
Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease
Background Parkinson's disease (PD) is histopathologically characterized by the loss of
dopamine neurons in the substantia nigra pars compacta. The depletion of these neurons is …
dopamine neurons in the substantia nigra pars compacta. The depletion of these neurons is …
[HTML][HTML] Clinical translation of stem cells in neurodegenerative disorders
O Lindvall, RA Barker, O Brüstle, O Isacson… - Cell stem cell, 2012 - cell.com
Stem cells and their derivatives show tremendous potential for treating many disorders,
including neurodegenerative diseases. We discuss here the challenges and potential for the …
including neurodegenerative diseases. We discuss here the challenges and potential for the …
Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease
KJ Doorn, PJ Lucassen, HW Boddeke, M Prins… - Progress in …, 2012 - Elsevier
Recent data has indicated that the traditional view of Parkinson's disease (PD) as an
isolated disorder of the nigrostriatal dopaminergic system alone is an oversimplification of its …
isolated disorder of the nigrostriatal dopaminergic system alone is an oversimplification of its …
Neural regeneration
Regeneration of the nervous system requires either the repair or replacement of nerve cells
that have been damaged by injury or disease. While lower organisms possess extensive …
that have been damaged by injury or disease. While lower organisms possess extensive …
Advantages and recent developments of autologous cell therapy for Parkinson's disease patients
TM Osborn, PJ Hallett, JM Schumacher… - Frontiers in Cellular …, 2020 - frontiersin.org
Parkinson's Disease (PD) is a progressive degenerative disease characterized by tremor,
bradykinesia, rigidity and postural instability. There are approximately 7–10 million PD …
bradykinesia, rigidity and postural instability. There are approximately 7–10 million PD …
Noradrenergic modulation of dopamine transmission evoked by electrical stimulation of the locus coeruleus in the rat brain
JW Park, RV Bhimani, J Park - ACS chemical neuroscience, 2017 - ACS Publications
Central norepinephrine (NE) and dopamine (DA) are involved in a variety of physiological
functions and behaviors. Accumulating evidence suggests that NE neurons originating from …
functions and behaviors. Accumulating evidence suggests that NE neurons originating from …
Proteomic profiling of the substantia nigra to identify determinants of Lewy body pathology and dopaminergic neuronal loss
Proteinaceous aggregates containing α-synuclein protein called Lewy bodies in the
substantia nigra is a hallmark of Parkinson's disease. The molecular mechanisms of Lewy …
substantia nigra is a hallmark of Parkinson's disease. The molecular mechanisms of Lewy …