From the very dawn of biological evolution, ATP was selected as a multipurpose energy-
storing molecule. Metabolism of ATP required intracellular free Ca2+ to be set at …

Ciliates are a diverse group of unicellular eukaryotes that vary widely in size, shape, body
plan, and ecological niche. Here, we review recent research advances achieved with ciliate …

Secretory granules, such as neuronal dense core vesicles, are specialized for storing cargo
at high concentration and releasing it via regulated exocytosis in response to extracellular …

As most of eukaryotic diversity lies in single‐celled protists, they represent unique
opportunities to ask questions about the balance of conservation and innovation in cell …

Membrane traffic can be studied by imaging a cargo protein as it transits the secretory
pathway. The best tools for this purpose initially block export of the secretory cargo from the …

The aim of the present article is to analyse the evolutionary links between protozoa and
neuronal and neurosecretory cells. To this effect we employ functional and topological data …

ABSTRACT Phage-encoded Shiga toxin (Stx) acts as a bacterial defense against the
eukaryotic predator Tetrahymena thermophila. It is unknown how Stx enters Tetrahymena …

Single-cell transcriptomics has the potential to provide novel insights into poorly studied
microbial eukaryotes. Although several such technologies are available and benchmarked …

Programmed nuclear death (PND) in the ciliate protozoan Tetrahymena thermophila is a
novel type of autophagy that occurs during conjugation, in which only the parental somatic …

Tetrahymena thermophila, a member of the Ciliates, represents a class of organisms
distantly related from commonly used model organisms in cell biology, and thus offers an …