Analyses in mouse models have revealed crucial roles for MafA (musculoaponeurotic
fibrosarcoma oncogene family A) and MafB in islet β cells, with MafB being required during …

Production and secretion of insulin from the β-cells of the pancreas is very crucial in
maintaining normoglycaemia. This is achieved by tight regulation of insulin synthesis and …

All pancreatic endocrine cell types arise from a common endocrine precursor cell
population, yet the molecular mechanisms that establish and maintain the unique gene …

Regulation of cell differentiation programs requires complex interactions between
transcriptional and epigenetic networks. Elucidating the principal molecular events …

Summary The transcription factor Neurogenin3 (Ngn3) is required for islet-cell type
specification. Here, we show that hepatic gene transfer of Ngn3 transiently induces insulin in …

Adenoviral, retroviral/lentiviral, adeno-associated viral, and herpesviral vectors are the major
viral vectors used in gene therapy. Compared with non-viral methods, viruses are highly …

Insulin is a critical hormone in the regulation of blood glucose levels. It is produced
exclusively by pancreatic islet β-cells. β-cell-enriched transcription factors, such as Pdx1 and …

Lineage-specific transcription factors (TFs) display instructive roles in directly
reprogramming adult cells into alternate developmental fates, in a process known as …

Reprogramming adult mammalian cells is an attractive approach for generating cell-based
therapies for degenerative diseases, such as diabetes. Adult human liver cells exhibit a high …

Recently, both estrogen receptor (ER) alpha and beta were detected in growth plate
chondrocytes of rats before sexual maturation, implying a role for estrogen at this stage. In …