IL-12 and IL-23 pathway inhibition in inflammatory bowel disease
Abstract Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …
[HTML][HTML] Parallels in immunometabolic adipose tissue dysfunction with ageing and obesity
Ageing, like obesity, is often associated with alterations in metabolic and inflammatory
processes resulting in morbidity from diseases characterised by poor metabolic control …
processes resulting in morbidity from diseases characterised by poor metabolic control …
Treatment-naïve HPV+ head and neck cancers display a T-cell-inflamed phenotype distinct from their HPV-counterparts that has implications for immunotherapy
Cancers progress when the immune system fails to identify and eliminate malignant cells.
Recognition of this, combined with advances in tumor immunology, has allowed …
Recognition of this, combined with advances in tumor immunology, has allowed …
Interleukin‐23 pathway at the enthesis: The emerging story of enthesitis in spondyloarthropathy
C Bridgewood, K Sharif, J Sherlock… - Immunological …, 2020 - Wiley Online Library
The inflammatory disorders collectively termed the seronegative spondyloarthropathies
(SpA) include ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, the …
(SpA) include ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, the …
Interactions between type 1 interferons and the Th17 response in tuberculosis: lessons learned from autoimmune diseases
BC Mourik, E Lubberts, JEM De Steenwinkel… - Frontiers in …, 2017 - frontiersin.org
The classical paradigm of tuberculosis (TB) immunity, with a central protective role for Th1
responses and IFN-γ-stimulated cellular responses, has been challenged by unsatisfactory …
responses and IFN-γ-stimulated cellular responses, has been challenged by unsatisfactory …
International union of basic and clinical pharmacology. CIX. Differences and similarities between human and rodent prostaglandin E2 receptors (EP1–4) and …
Prostaglandins are derived from arachidonic acid metabolism through cyclooxygenase
activities. Among prostaglandins (PGs), prostacyclin (PGI2) and PGE2 are strongly involved …
activities. Among prostaglandins (PGs), prostacyclin (PGI2) and PGE2 are strongly involved …
cAMP: a multifaceted modulator of immune synapse assembly and T cell activation
VB Arumugham, CT Baldari - Journal of Leucocyte Biology, 2017 - academic.oup.com
T Lymphocyte activation involves a substantial reorganization of the membranous and
intracellular compartments. Signaling complexes assemble and dismantle in a highly …
intracellular compartments. Signaling complexes assemble and dismantle in a highly …
The star target in SLE: IL-17
Y Yang, C Yan, L Yu, X Zhang, J Shang, J Fan… - Inflammation …, 2023 - Springer
Purpose The purpose of this review is to discuss the significance of IL-17 in SLE and the
potential of IL-17-targeted therapy. Background Systemic lupus erythematosus (SLE) is an …
potential of IL-17-targeted therapy. Background Systemic lupus erythematosus (SLE) is an …
Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer
J Ke, Y Yang, Q Che, F Jiang, H Wang, Z Chen, M Zhu… - Tumor Biology, 2016 - Springer
Abstract Prostaglandin E2 (PGE2), a derivative of arachidonic acid, has been identified as a
tumorigenic factor in many cancers in recent studies. Prostaglandin E synthase 2 (PTGES2) …
tumorigenic factor in many cancers in recent studies. Prostaglandin E synthase 2 (PTGES2) …
Integrating longitudinal serum IL-17 and IL-23 follow-up, along with autoantibodies variation, contributes to predict bullous pemphigoid outcome
J Plée, S Le Jan, J Giustiniani, C Barbe, P Joly… - Scientific Reports, 2015 - nature.com
Bullous pemphigoid (BP) is an inflammatory autoimmune bullous disease involving
cytokines and proteases in the process of blister formation. Recently, IL-17 and IL-23 were …
cytokines and proteases in the process of blister formation. Recently, IL-17 and IL-23 were …